Synthesis of 5-(Fluoroalkyl)isoxazole Building Blocks by Regioselective Reactions of Functionalized Halogenoximes
A comprehensive study on the synthesis of 5-fluoroalkyl-substituted isoxazoles starting from functionalized halogenoximes is reported. One-pot metal-free [3 + 2] cycloaddition of CF3-substituted alkenes and halogenoximes bearing ester, bromo, c
Chalyk, Bohdan A.,Hrebeniuk, Kateryna V.,Fil, Yulia V.,Gavrilenko, Konstantin S.,Rozhenko, Alexander B.,Vashchenko, Bohdan V.,Borysov, Oleksandr V.,Biitseva, Angelina V.,Lebed, Pavlo S.,Bakanovych, Iulia,Moroz, Yurii S.,Grygorenko, Oleksandr O.
p. 15877 - 15899
(2019/11/13)
AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS
Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.
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Page/Page column 212
(2010/04/27)
BENZAZEPIN-2(1H)-ONE DERIVATIVES
Compounds of formula (I) and pharmaceutically acceptable salts thereof are agonists at the beta-2 adrenoceptor. They are useful as feed additives for livestock animals.
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Page/Page column 52
(2008/06/13)
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