Indolin-2-one p38α inhibitors II: Lead optimisation
Optimisation of a series of indolin-2-one p38α inhibitors was achieved via both blocking of a potential metabolic 'hot spot' and by increasing overall polarity of the lead series leading to non-cytotoxic compounds which showed improved oral bioavailabilities in the rat.
Eastwood, Paul,González, Jacob,Gómez, Elena,Caturla, Francisco,Balagué, Cristina,Orellana, Adelina,Domínguez, María
p. 5270 - 5273
(2011/10/09)
Substituted aza-oxindole derivatives
Substituted aza-oxindole derivatives useful as cyclin dependent kinase 11 inhibitors, for preventing/reducing the severity of epithelial cytotoxicity side-effects (e.g., alopecia, plantar-palmar syndrome, mucositis) induced by chemoptherapy and/or radiati
-
(2008/06/13)
3-(anilinomethylene) oxindoles
The present invention relates generally to novel amine substituted oxindole compounds and compositions. Such compounds and compositions have utility as pharmacological agents in treating diseases or conditions alleviated by the inhibition or antagonism of
-
Page column 70-71
(2010/02/04)
Substituted oxidole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors
-
-
(2008/06/13)
More Articles about upstream products of 220896-14-0