Rationally designed 4-phenoxy substituted prolinamide phenols organocatalyst for the direct aldol reaction in water
A rationally designed 4-phenoxy substituted prolinamide phenols as an efficient hydrophobic organocatalyst for direct asymmetric aldol reaction in water has been developed. High yield (up to 99%), diastereoselectivity (up to 99:1), and enantioselectivity (up to 97%) were obtained under optimal condition. The influence of substituent groups on the reactivity of catalysts was studied in detail. Crown Copyright
Zhang, Shu-peng,Fu, Xiang-kai,Fu, Shao-dong
supporting information; experimental part
p. 1173 - 1176
(2009/06/28)
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