- Solid phase synthesis of 1,3,5-trisubstituted pyridin-2-ones
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The solid phase synthesis of 1,3,5-trisubsituted pyridin-2-ones is reported via selective 1NH-alkylation of 3-amino-5-carbomethoxy-1H-pyridin- 2-one with a solid-supported halo-acid. Coupling of an acid to solid- supported 3-aminopyridinone was
- Linn, James A.,Gerritz, Samuel W.,Handlon, Anthony L.,Hyman, Clifton E.,Heyer, Dennis
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- INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE
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The invention provides indazolyl thiadiazolamines and related compounds, pharmaceutical compositions, methods of inhibiting Rho-associated protein kinase, and methods of treating inflammatory disorders, immune disorders, fibrotic disorders, and other medical disorders using such compounds. An exemplary indazolyl thiadiazolamine compound is an N-(5-[5-[(1H4ndazol-5-yl)amino]-1,3,4-thiadiazol-2-yl]pyridin-3-yl)acetamide compound.
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Paragraph 00373
(2016/09/22)
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