- Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia
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α-Aminonitrile was an important building block in natural products and key intermedia in organic chemistry. Herein, the direct amination of cyanohydrins with the partner of ammonia to synthesis N-unprotected α-aminonitriles is developed. The reaction proceeds via titanium-catalyzed cyano-borrowing reaction, which features high atom economy and simple operation. A broad range of ketone or aldehyde cyanohydrins was tolerated with ammonia, and the N-unprotected α-aminonitriles were synthesis with moderate to high yields under mild reaction conditions.
- Li, Qing-Hua,Li, Zhao-Feng,Tao, Jing,Li, Wan-Fang,Ren, Li-Qing,Li, Qian,Peng, Yun-Gui,Liu, Tang-Lin
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supporting information
p. 8429 - 8433
(2019/10/14)
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- Approaches to the construction of substituted 4-amino-1 H -pyrrol-2(5 H)-ones
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Fully substituted 4-aminopyrrolones are easily accessed via simple routes starting from imines, ketones, or α-bromophenyl acetonitriles. Imines were reacted with KCN/NH4Cl in aqueous ethanol to produce α-arylamino benzyl cyanides. On the other hand, ketones were transformed to the desired α-amino nitriles using a modified Strecker reaction. Then, α-amino nitrile precursors were allowed to react with a suitable acyl halide to produce the corresponding amides. Further treatment of these amides with ethanolic KOH converted them to highly substituted 4-amino-1H-pyrrol-2(5H)- one derivatives in moderate to excellent yields.
- Zali-Boeini, Hassan,Mobin, Mehdi,Hajibabaei, Khadijeh,Ghani, Maryam
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experimental part
p. 5808 - 5812
(2012/07/31)
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- Methods and compositions for treating amyloid-related diseases
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Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
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Page/Page column 165-166
(2010/11/24)
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- Helical versus planar conformation of homooligopeptides prepared from diethylglycine (= 2-amino-2-ethylbutanoic acid)
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Homooligopeptides containing α,α-diethylgycine (=2-amino-2- ethylbutanoic acid), were synthesized by conventional solution methods. An ethyl or methyl ester was used as protecting group at the C-terminus and a trifluoroacetyl group as protecting group at the N-terminus of the peptides. The conformations of such tripenta-, and hexapeptides in the solid state were studied using X-ray crystallographic analysis, and were shown to be a bent planar C5-conformation in the case of tripeptide 8a, and a 310-helical structure in the case of pentapeptide 10 and hexapeptide 11. 1R and 1H-NMR spectra revealed that the dominant conformation of hexapeptide 11 in CDCl3 solution was not the 310-helical structure shown in the solid state, but a fully planar C5 structure.
- Tanaka, Masakazu,Imawaka, Naoto,Kurihara, Masaaki,Suemune, Hiroshi
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p. 494 - 510
(2007/10/03)
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- Method for controlling the relative stem growth of plants
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The invention relates to a method for controlling the relative stem growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of a dihydroimidazoisoindoledione or an optical or stereo isomer thereof.
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- Method for inhibiting bud growth of plants
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The invention relates to a method for inhibiting the bud growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of a dihydroimidazoisoindoledione or an optical or stereo isomer thereof.
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- Method for inhibiting bud growth of plants
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The invention relates to a method for inhibiting the bud growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of an imidazoisoindoledione or an optical or stereo isomer thereof.
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- Method for controlling the relative stem growth of plants
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The invention relates to a method for controlling the relative stem growth of plants by applying to the foliage of the plants, or to soil containing seeds of the plants, a plant-growth-regulating amount of an imidazoisoindoledione or dihydroimidazoisoindoledione or an optical or stereo isomer thereof.
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- Imidazoisoindolediones and the use thereof as herbicidal agents
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The invention relates to novel imidazoisoindoledione compounds including the optical isomers thereof. This invention also relates to a method for the control of undesirable plant species with the imidazoisoindolediones and their optical isomers, and further, to a process for the preparation of the compounds.
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