- COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE
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The present disclosure provides amide-based, non-nucleoside compounds having an inhibitory activity against endogenous polymerases, such as polymerase alpha and polymerase gamma. This disclosure further provides uses of treating hyperproliferative disease
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Page/Page column 76
(2008/12/06)
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- NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF
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The present dislcosure provides amide-based, non-nucleoside compounds having antiviral activity against Hepacivirus, such as hepatitis C virus (HCV), methods and intermediates for synthesizing such compounds, and methods of using the compounds in a variety of contexts, including in the treatment and prevention of viral infections. The present dislcosure also provides methods for identifying amide-based, non-nucleoside compounds having antiviral activity.
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Page/Page column 77
(2010/11/25)
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- Identification of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library
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Two orthogonal peptide combinatorial libraries were screened to discover inhibitors of Tc80 protease, a novel target from Trypanosoma cruzi involved in host cell invasion. These libraries were composed of 15625 structurally diversified tripeptides, partit
- Vendeville, Sandrine,Buisine, Eric,Williard, Xavier,Schrevel, Joseph,Grellier, Philippe,Santana, Jaime,Sergheraert, Christian
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p. 194 - 198
(2007/10/03)
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