- cGAS ANTAGONIST COMPOUNDS
-
Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.
- -
-
Paragraph 0216; 0225; 0236
(2017/11/06)
-
- NOVEL SULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION
-
The present invention relates to compounds of formula (I), wherein R 1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.
- -
-
Page/Page column 153
(2016/12/01)
-
- SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF
-
Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
- -
-
Page/Page column 387
(2014/09/29)
-
- SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF
-
Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.
- -
-
Paragraph 0309; 0310
(2014/09/30)
-
- Benzamides
-
The present invention is directed to benzamide containing compounds which inhibit the P2X7 receptor
- -
-
Paragraph 0121
(2014/05/07)
-
- AMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF
-
Compounds are provided according to formula (I), where A, B, W, X', L, R1, R3, R4b, and m' are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
- -
-
Page/Page column 80-81
(2010/04/25)
-
- 2-Cyanophenyl fused heterocyclic compounds, and compositions and uses thereof
-
Fused heterocyclic compounds are provided according to formula 1: where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.
- -
-
Page/Page column 29
(2008/12/08)
-
- (2,5)Pyrimidinophanes: Synthesis and Molecular Structure
-
The title compounds 1 and 2 are synthesized by photolytic sulfur extrusion from 2,11-dithia(2,5)pyrimidinophane 17.The molecular structures of 1 and 2 are determined by X-ray structure analysis and are discussed with regard to the steric strain in these molecules.Thermolysis of - or -trimethylammonium hydroxide (10 or 11) does not generate 1 and 2. α-Chlorination of 2,5-dimethylpyrimidine (3) with N-chlorosuccinimide provides the required precursors 4 - 6.
- Eiermann, Uwe,Krieger, Claus,Neugebauer, Franz A.
-
p. 1885 - 1889
(2007/10/02)
-