- Synthesis method of pharmaceutical synthesis intermediate acetylcholine iodide
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The invention relates to a synthesis method of a pharmaceutical synthesis intermediate acetylcholine iodide. The method mainly includes the steps of: adding 3mol 3, 5-dhydroxyl-4-acetyl toluene and 4-5mol choline iodide into a reaction container, controlling the stirring speed at 110-130rpm, raising the temperature to 60-65DEG C, maintaining the temperature and performing stirring continuously until complete dissolution, conducting standing for 90-120min, lowering the solution temperature to 10-15DEG C, precipitating crystals, performing filtration, washing the crystals with a cyclohexane solution and a toluene solution, and conducting dehydration with a dehydrating agent, thus obtaining the finished product acetylcholine iodide.
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Paragraph 0011; 0013; 0015
(2018/07/30)
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