Dynamic NMR studies of a potential chiroptical switch based on dithiocarbamate-iminodithiolane interconversion
Equation presented Variable temperature NMR spectra of the chiral spiro[(4-N,N-dimethyldithiocarbamato)-(2-N,N-dimethylimino)-1,3-dithiolane-5, 9′-xanthene] show complex dynamics including degenerate interconversion of the dithiocarbamate and iminodithiolane groups. The rate of this switching process can be controlled by chemical modification: the analogous spiro[dithiolane-fluorene] derivative shows no interconversion. These novel materials have potential application as molecular switching elements in information storage devices.
Aubin, Lauren B.,Wagner, Tracy M.,Thoburn, John D.,Kesler, Brenda S.,Hutchison, Katherine A.,Schumaker, Robert R.,Parakka, James P.
An approach to biologically important S-heterocycles, dithiocarbamyls, and their relevant phosphono derivatives
The feasibility of insertions of carbanions between two sulfur atoms has been reported when 5-(4-chlorophenyl)-4-cyano-1,2-dithiol-3-thione (1) and tetramethylthiuram disulfide (17) were allowed to react with unsaturated 2a,b and active phosphonium salts
Khidre, Maha D.,Kamel, Azza A.,Abdou, Wafaa M.
p. 103 - 108
(2007/10/03)
Hapten synthesis for the development of a competitive inhibition enzyme-immunoassay for thiram
An enzyme-linked immunosorbent assay (ELISA) was developed for the fungicide thiram. Two types of haptens were synthesized. The first type exhibits the two symmetrical N-alkyl dithiocarbamate patterns of thiram with a spacer arm linked to one of the N-methyl terminal group. The second type exhibits one of the two symmetrical N-alkyl dithiocarbamate patterns of thiram with a variable-length spacer arm linked to one sulfur atom. Polyclonal antibodies suitable for thiram detection were obtained from immunization with an hapten of the first type, while haptens of the second type were used as coating antigens to develop a competitive ELISA against thiram. The IC50 value for thiram was estimated to be 0.24 μg/mL, with a detection limit of 0.03 μg/mL. The assay seems to be thiram-specific since no or little cross-reaction with other dithiocarbamates were observed.