- 3-PHENYLSULPHONYL-QUINOLINE DERIVATIVES AS AGENTS FOR TREATING PATHOGENIC BLOOD VESSELS DISORDERS
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The disclosure provides compounds, and compositions, including pharmaceutical compositions, kits that include the compounds, and methods of using (or administering) and making the compounds. The disclosure further provides compounds or compositions thereof for use in a method of modulating PLXDC1 (TEM7) and/or PLXDC2 or killing pathogenic blood vessles. The disclosure further provides compounds or compositions thereof for use in a method of treating a disease, disorder, or condition that is mediated, at least in part, by PEDF receptors or by angiogenesis.
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- Natural product-based design, synthesis and biological evaluation of anthra[2,1-d]thiazole-6,11-dione derivatives from rhein as novel antitumour agents
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Two series of novel 2-substituted 5,7-dihydroxyanthra[2,1-d]thiazole-6,11- dione derivatives from natural rhein were designed, synthesized and evaluated for their antitumour activities against human cancer cell lines A549 and HeLa in vitro.
- Liang, Yu-Kun,Yue, Zhi-Zhou,Li, Jia-Xin,Tan, Cun,Miao, Ze-Hong,Tan, Wen-Fu,Yang, Chun-Hao
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p. 505 - 515
(2014/08/05)
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- Piperazine derivatives with anticholinergic and/or antihistaminic activity
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Compounds of formula I STR1 are described in which R is an aryl, substituted aryl, aralkyl or heterocyclic radical; R1 is hydrogen or alkyl of 1-4 carbon atoms; A is a saturated, aliphatic hydrocarbon chain, which is linear or branched; R2
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