A selective and practical method has been developed for the synthesis of penciclovir (1) in gram quantities involving a highly N9 selective alykylation of 2-amino-6-chloropurine (9) with 2-(2-phenyl-1,3-dioxane-5-yl)ethanol (12) as a key step.
Toyokuni, Tatsushi,Walsh, Joseph C.,Namavari, Mohammad,Shinde, Shirin S.,Moore, Jennifer R.,Barrio, Jorge R.,Satyamurthy, Nagichettiar