cas 22788-18-7, carboxyphosphamide | Articles data ｜lookchem

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22788-18-7

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Effect of damaged liver parenchyma, renal insufficiency and hemodialysis on the pharmacokinetics of cyclophosphamide and its activated metabolites
Patients with impaired liver function have a reduced biotransformation rate of the cytostatic agent cyclophosphamide. With pathologically reduced serum cholinesterase activity the half-life of the drug increases from normally 4.3 h to 6.7 h. These patients show significantly lower peak levels of activated cyclophosphamide (4-hydroxy-cyclophosphamide + aldophosphamide). Because of the low renal clearance of cyclophosphamide (16 ml/min) and equally low renal excretion of activated cyclophosphamide amounting to only 1% of the applied dose more than 80% of the drug is still metabolized and the area under the curve of activated cyclophosphamide (cXt) remains relatively constant. No change in the pharmacokinetics of cyclophosphamide and its activated metabolite is observed in an anuric patient. However, an accumulation of toxic, directly alkylating metabolites with a fourfold alkylation rate of plasma proteins is found in this case. Hemodialysis sufficiently eliminated the toxic alkylating metabolites without a measurable influence on the pharmacokinetics of activated cyclophosphamide.
Wagner,Heydrich,Bartels,Hohorst
p. 1588 - 1592
(2007/10/02)

Studies on cyclophosphamide metabolites and their related compounds. I.
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Takamizawa,Tochino,Hamashima,Iwata
p. 1612 - 1616
(2007/10/04)

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Chemical Properties

Melting Point: 105-108°C
Boiling Point: 447.4°Cat760mmHg
Flash Point:224.3°C
Density: 1.444g/cm³
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Vapor Pressure: 2.99E-09mmHg at 25°C
PSA: 102.67000
LogP: 2.02440

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