2283-16-1

Five saturated α-branched fatty acids, also known as Guerbet acids, including α-propylhexyl acid (G 1 ), α-butylhexyl acid (G 2 ), α-propyloctyl acid (G 3 ), α-butyloctyl acid (G 4 ), and α-hexyloctyl acid (G 5 ), were synthesized in high yields by four-step reaction. Colorless, almost odorless, and oily products were obtained with high purity, whose structures were confirmed by GC, 1H/13C NMR, and ESI-MS characterization. G 1, G 3, and G 4 had pour points lower than -60 °C, while G 2 and G 5 showed higher pour points (-42 °C and 6 °C, respectively) because of their molecular symmetry. Considering the low-temperature properties, G 1, G 3, G 4, and even G 2 held great potential applications in the lubricant and oilfield.

The invention discloses a method for preparing Guerbet acids by taking malonate as a raw material. The method comprises the following steps: using the malonate as the raw material, and carrying out alkylation reaction under the action of alkali to obtain dialkyl malonate; sequentially carrying out hydrolysis reaction and decarboxylic reaction on obtained dialkyl malonate to obtain the Guerbet acid, wherein the malonate is dimethyl malonate or diethyl malonate; the alkali of the alkylation reaction is selected from one or more of potassium carbonate, sodium hydroxide, potassium hydroxide, sodium methylate and sodium ethoxide; an alkylating reagent is haloalkane with 2 to 20 carbons. According to the method disclosed by the invention, the Guerbet acids are prepared by taking the malonate as the raw material for the first time; related three reactions are easily operated, high temperature or high pressure is not needed, and high yield is realized; by means of the alkylation reaction disclosed by the invention, a main chain structure and a branched chain structure of the Guerbet acids can be flexibly regulated and controlled, and further the Guerbet acids with different properties are obtained.

Microwave induced hydrolysis of alkyl Medrum's acids and decarboxylation of derived malonic acids using poly-4-vinylpyridine as a catalyst gives high yields of carboxylic acids in a short time.

It has been found that substituents on N,N'-bis (8-quinolyl)malonamide play an important role in copper(II) extraction: among the substituents studied, benzyl groups dramatically increased extractability of the malonamide complex.The role of substituents is discussed on the basis of the results of titration and 1H NMR measurements of copper(II) or nickel(II) complexes as well as copper(II)-extraction experiments.Intramolecular interactions between ? electrons of the benzyl group and the metal centre of the complex are proposed to occur.

Useful antibacterial agents in which a penicillin and/or a beta-lactamase inhibitor are linked via 1,1-alkanediol dicarboxylates are of the formula STR1 where A is the residue of certain dicarboxyic acids, R3 is H or (C1 -C3), n is zero or 1 such that when n is zero R is P or B and R1 is the residue of certain esters, H or a salt thereof; and when n is 1, one of R and R1 is P and the other is B, and P is STR2 where R2 is H or certain acyl groups, and B is the residue of a beta-lactamase inhibiting carboxylic acid; a method for their use, pharmaceutical compositions thereof and intermediates useful in their production.