- Novel indole-N-glucoside, TA-1887 As a sodium glucose cotransporter 2 inhibitor for treatment of type 2 diabetes
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Inhibition of the renal sodium glucose cotransporter (SGLT) increases urinary glucose excretion (UGE) and thus reduces blood glucose levels during hyperglycemia. To explore the potential of new antihyperglycemic agents, we synthesized and determined the h
- Nomura, Sumihiro,Yamamoto, Yasuo,Matsumura, Yosuke,Ohba, Kiyomi,Sakamaki, Shigeki,Kimata, Hirotaka,Nakayama, Keiko,Kuriyama, Chiaki,Matsushita, Yasuaki,Ueta, Kiichiro,Tsuda-Tsukimoto, Minoru
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- Synthesis of 1,3- and 2,3-diglycosylated indoles as potential trisaccharide mimetics
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Diglycosylated heteroaromatics may serve as metabolically stable mimetics of trisaccharides. Herein, the preparation of several 1,3- and 2,3-diglycosylindoles by direct C-glycosylation of monoglycosylated precursors is described. Georg Thieme Verlag Stuttgart ? New York.
- Wiebe, Christine,Fust De La Sotilla, Silvia,Opatz, Till
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experimental part
p. 1385 - 1397
(2012/07/13)
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- Sweet (hetero)aromatics: Glycosylated templates for the construction of saccharide mimetics
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Mono- and diglycosylated aromatics and heteroaromatics may serve as building blocks for the construction of metabolically stable mimetics of oligosaccharides. Methods for their preparation from monosaccharidic precursors by direct C-glycosylation, dipolar cycloaddition or Larock cyclization are described.
- Wiebe, Christine,Schlemmer, Claudine,Weck, Stefan,Opatz, Till
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p. 9212 - 9214
(2011/10/04)
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- Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives
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In the course of structure-activity relationship studies, diversely substituted 1-(β-D-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies.
- Sassatelli, Mathieu,Bouchikhi, Fadoua,Messaoudi, Samir,Anizon, Fabrice,Debiton, Eric,Barthomeuf, Chantal,Prudhomme, Michelle,Moreau, Pascale
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- Synthesis of 1-glycosyl derivatives of benzocamalexin
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The linear synthesis of 1-(β-o-glucopyranosyl)-, 1-(β-D- galactopyranosyl)-, 1-(β-D-mannopyranosyl)- and 1-(β-D-ribofuranosyl) benzocamalexin was elaborated from indoline as a starting compound and corresponding pentaacetylhexoses or 1-O-acetyl-2,3,5-tri-
- Humenik, Martin,Dzurilla, Milan,Kutschy, Peter,Solcaniova, Eva,Kovacik, Vladimir,Bekesova, Slavka
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p. 1657 - 1674
(2007/10/03)
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