First regioselective c-2 lithiation of 3- and 4-chloropyridines
We have shown that the BuLi/LiDMAE reagent promotes the clean and regioselective C2 lithiation of 3- and 4-chloropyridines, while other reagents such as LDA or BuLi/TMEDA lead to classical ortho lithiation products or mixtures of regioisomers. The method was successfully applied to the preparation of various reactive 2,3- and 2,4-disubstituted pyridines.
Choppin, Sabine,Gros, Philippe,Fort, Yves
p. 603 - 606
(2007/10/03)
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