Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa
A series of thiophene-containing non-amidine factor Xa inhibitors is described. Simple methyl-substituted thiophene analogs were relatively weak inhibitors. However, introduction of hydrophilic substituents at C-4 or C-5 of the thiophene afforded inhibito
Kochanny, Monica J.,Adler, Marc,Ewing, Janice,Griedel, Brian D.,Ho, Elena,Karanjawala, Rushad,Lee, Wheeseong,Lentz, Dao,Liang, Amy M.,Morrissey, Michael M.,Phillips, Gary B.,Post, Joseph,Sacchi, Karna L.,Sakata, Steven T.,Subramanyam, Babu,Vergona, Ron,Walters, Janette,White, Kathy A.,Whitlow, Marc,Ye, Bin,Zhao, Zuchun,Shaw, Kenneth J.
p. 2127 - 2146
(2008/02/01)
ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS
This invention is directed to compounds of formula (III): STR1 wherein B, C, D, E, R 1, R 2 and R 3 are disclosed herein. These compounds are disclosed as being useful as anti-coagulants.
-
(2008/06/13)
More Articles about upstream products of 229339-69-9