New furin inhibitors based on weakly basic amidinohydrazones
A novel series of amidinohydrazone-derived furin inhibitors was prepared; the most potent compounds 17 and 21 inhibit furin with Ki values of 0.46 and 0.59 μM, respectively. In contrast to inhibitor 17, which still contains a guanidino residue,
Sielaff, Frank,Than, Manuel E.,Bevec, Dorian,Lindberg, Iris,Steinmetzer, Torsten
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p. 836 - 840
(2011/02/27)
STUDIES ON METHYLGLYOXAL BIS(GUANYLHYDRAZONE) ANALOGS. II. STRUCTURAL