- Synthesis and crystal structure of 5-bromoisophthalic acid
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A new compound viz., 5-bromoisophthalic acid with the molecular formula C8H7BrO5 has been successfully synthesized by the reaction of isophthalic acid and N-bromosuccinimide (NBS). The compound has been characterized by X-ray single-crystal diffraction and shows a one-dimensional framework. The 3D supramolecular structure is formed via hydrogen bonding connection.
- Zhang,Zhang
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- A NbO-type metal-organic framework exhibiting high deliverable capacity for methane storage
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A copper-based NbO-type metal-organic framework ZJNU-50 constructed from a tetracarboxylate incorporating phenylethyne as a spacer exhibited an exceptionally high methane working capacity of 184 cm3 (STP) cm-3 for methane storage. The value is among the highest reported for MOF materials. This journal is
- Song, Chengling,Ling, Yajing,Feng, Yunlong,Zhou, Wei,Yildirim, Taner,He, Yabing
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- A new route for the preparation of 5-hydroxyisophthalic acid
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A new, simple and practical, two-stage process for the preparation of 5-hydroxyisophthalic acid (5-HIPA) from isophthalic acid is described. In the first stage, isophthalic acid is brominated by bromine in oleum, in the presence of an iodine catalyst, to give crude 5-bromoisophthalic acid (5-BIPA). In the second stage the crude 5-BIPA is hydrolyzed with aqueous NaOH, in the presence of a copper catalyst, to give crude 5-HIPA, with a purity of ca. 98%. Both stages of the process were optimized. A single crystallization of the crude 5-HIPA from water gives the product in a purity of more than 99%. The overall yield of pure 5-HIPA is 65-70%.
- Gelmont, Mark,Oren, Jakob
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- COMPOSITIONS AND METHODS FOR SELECTIVE SEPARATION OF HYDROCARBON ISOMERS
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The present invention relates to novel metal-organic frameworks (MOFs) comprising tetratopic linkers with small pore apertures. The present invention further relates to methods of utilizing the MOFs of the invention to separate hydrocarbons through adsorptive processes. The present invention further relates to the discovery that Ca(H2tcpb) metal-organic framework (MOF) is capable of separating hydrocarbon isomers from one another through absorptive processes. In one aspect, the invention provides a method of separating C5-C8 hydrocarbon isomers, such that straight chain, mono-branched, and/or multi-branched isomers are each separated from one another. In certain embodiments, this separation is achieved by taking advantage of the temperature dependent adsorptive properties of Ca(H2tcpb) MOF.
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(2019/08/29)
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- Anthraquinone compound and its preparation method and medical use (by machine translation)
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The invention relates to a anthraquinone compound and its preparation method and medical use, cheap and easy to get to the isophthalic acid as the starting material, through the bromo, hydrolysis, esterification of the obtained intermediate with 2 - bromo - 5 - methoxy acyl chloride condensation, condensation product after hydrolysis, loop, debromination reduction to obtain the target product 1, 5 - dihydroxy - 3 - carboxyl - 9, 10 - anthraquinone. The reaction of the invention cheap, low cost, simple operation, high yield. Anti-tumor activity study results display, artificial synthesis of 1, 5 - dihydroxy - 3 - carboxyl - 9, 10 - anthraquinone has better anti-tumor activity. (by machine translation)
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Paragraph 0006; 0010
(2017/08/30)
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- Monocrystalline iron metal organic frameworks
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The invention relates to large single crystals of iron metal-organic framework materials comprising at least one iron metal ion, processes for preparing the same, methods for employing the same, and the use thereof. The invention also relates to monocrystalline and polycrystalline iron metal-organic frameworks.
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Paragraph 0163; 0164
(2015/06/03)
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- Aluminum Metal Organic Framework Materials
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The invention relates to monocrystalline single crystals of metal-organic framework materials comprising at least one aluminium metal ion, processes for preparing the same, methods for employing the same, and the use thereof. The invention also relates to monocrystalline aluminium metal-organic frameworks.
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Paragraph 0156; 0157; 0158
(2019/07/30)
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- COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS
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The present disclosure is directed to corn- pounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders. The methods generally comprise administering to a mammal in need thereof a pharmaceutically effective amount of a compound, or a pharmaceutical composition comprising such a compound, that is designed to be substantially active in the gastrointestinal (GI) tract to inhibit NHE-mediated antiport of sodium ions and hydrogen ions therein. More particularly, the method comprises administering to a mammal in need thereof a pharmaceutically effective amount of a compound, or a pharmaceutical composition comprising such a compound, that inhibits NHE-3, -2 and/ or -8 mediated antiport of sodium and/or hydrogen ions in the GI tract and is designed to be substantially impermeable to the layer of epithelial cells, or more specifically the epithelium of the GI tract. As a result of the compound being substantially impermeable, it is not absorbed and is thus essentially systemically non-bioavailable, so as to limit the exposure of other internal organs (e.g., liver, heart, brain, etc.) thereto. The present disclosure is still further directed to a method wherein a mammal is administered such a compound with a fluid-absorbing polymer, such that the combination acts as described above and further provides the ability to sequester fluid and/or salt present in the GI tract
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(2010/08/04)
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- Bromination of deactivated aromatics: A simple and efficient method
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(Chemical Equation Presented) Highly deactivated aromatic compounds were smoothly monobrominated by treatment with N-bromosuccinimide (NBS) in concentrated H2SO4 medium affording the corresponding bromo derivatives in good yields. Mild reaction conditions and simple workup provides a practical and commercially viable route for the synthesis of bromo compounds of deactivated aromatics.
- Rajesh,Somasundaram,Saiganesh,Balasubramanian
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p. 5867 - 5869
(2008/02/09)
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- MACROCYCLIC TERTIARY AMINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
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The present invention is directed to macrocyclic tertiary amine compounds represented by general formula (I), which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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(2010/11/08)
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- METAL COMPLEX COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE CONTAINING THE SAME
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A metal-complex compound having a special structure containing metals such as iridium. An organic electroluminescence device which comprises at least one organic thin film layer sandwiched between a pair of electrode consisting of an anode and a cathode, wherein the organic thin film layer comprises the metal-complex compound, which emits light by applying an electric voltage between the pair of electrode. An organic EL device employing the novel metal-complex compound emits various phosphorous light including blue light having an enhanced current efficiency and prolonged lifetime.
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(2010/11/08)
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- Process for the preparation of bromoisophthalic acid compounds
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The present invention relates to a process for preparing bromoisophthalic acid compounds, particularly 5-bromoisophthalic acid compounds and 4,5-dibromoisophthalic acid compounds comprising brominating an isophthalic acid compound of the general formula (1) wherein R1 and R2 independently of one another are hydrogen atom or C1-6 alkyl, with bromine in a solvent containing sulfur trioxide. The object of the invention is to provide a process for preparing bromoisophthalic acid compounds, particularly 5-bromoisophthalic acid compounds and 4,5-dibromoisophthalic acid compounds in a highly selective manner by using bromine that is industrially inexpensive.
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- Vitamin D analogues
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The invention concerns novel bi-aromatic compounds having the formula: which are analogs of vitamin D, the process of preparing them, as well as their use in pharmaceutical compositions in human or veterinary medicine, particularly in dermatology, cancer treatment, treatment of auto-immune diseases, and in organ or tissue transplants. Cosmetic compositions and methods of use are also included.
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(2010/02/05)
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- AROMATIC CARBOXYLIC ACIDS, ACID HALIDES THEREOF AND PROCESSES FOR PREPARING BOTH
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A novel aromatic carboxylic acid useful as a material for macromolecular compounds and, in particular, for polycondensed macromolecular compounds exhibiting excellent heat resistance, an acid halide derivative thereof and a process for producing these compounds are disclosed. The aromatic carboxylic acid and the acid halide derivative thereof have structures represented general formulae (1) and (2), respectively, and can be efficiently produced from a dialkyl ester derivative of isophthalic acid and an acetylene derivative in accordance with the disclosed process comprising specific steps. In the above formulae, A represents:- C≡C-R1 or (R1 represents hydrogen atom, an alkyl group or an aromatic group, R2 represents an alkyl group or an aromatic group) and X represents a halogen atom.
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- PROCESS FOR THE PREPARATION OF BROMOISOPHTHALIC ACID COMPOUNDS
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The present invention relates to a process for preparing bromoisophthalic acid compounds, particularly 5- bromoisophthalic acid compounds and 4,5-dibromoisophthalic acid compounds comprising brominating an isophthalic acid compound of the general formula (1)wherein R1and R2independently of one another are hydrogen atom or C1-6alkyl, with bromine in a solvent containing sulfur trioxide. The object of the invention is to provide a process for preparing bromoisophthalic acid compounds, particularly 5-bromoisophthalic acid compounds and 4,5-dibromoisophthalic acid compounds in a highly selective manner by using bromine that is industrially inexpensive.
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- 1-(Aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
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Certain 1-(aromatic- or heteroaromatic-substituted-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
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- Optically active C3-symmetric triarylphosphines in asymmetric allylations
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A new class of optically active, monodentate, C3-symmetric ligands for asymmetric catalysis, 1-3, were prepared via routes involving asymmetric reduction of aryl ketones (Schemes 1-3). Single crystal X-ray structures of trans-PdCl2(phosphine)2 complexes of ligands 1a, 2a and 3a showed that the ligands do not adopt perfect C3-symmetric conformations in the solid state; in fact, all three have one aromatic ring lying 'face-on' to the metal. Circular dichroism studies of the same complexes provided some evidence for an aromatic ordering effect for complex 22, but none for 21 and 23. Palladium catalyzed allylation reactions using ligands 1-3 showed that encouraging enantioselectivities could be obtained, particularly for cyclic, allylic substrates.
- Powell, Mark T.,Porte, Alexander M.,Reibenspies, Joe,Burgess, Kevin
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p. 5027 - 5038
(2007/10/03)
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- Synthesis of nitronyl- and imino-nitroxide-triradicals interconnected by phenyl ethynyl spacer
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The design and synthesis, as well as solid state and ESR characterisation of three new triradicals based on phenyl ethynyl backbone bearing nitronyl-nitroxide and imino-nitroxide groups, are reported. The synthesis of these compounds was based on palladium-coupling reactions between alkynyl and bromo derivatives. An ESR study showed magnetic interactions between the radicals through the phenyl ethynyl-coupling unit in solution. (C) 2000 Elsevier Science Ltd.
- Catala, Laure,Turek, Philippe,Le Moigne, Jacques,De Cian, André,Kyritsakas, Nathalie
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p. 1015 - 1018
(2007/10/03)
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- Aromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor
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Aromatic analogs of arcaine were shown to have inhibitory effects on the binding of the channel blocking drug [3H]MK-801 to the NMDA receptor complex. The most potent compound of the series was an N,N - bis(propyl)guanidinium which inhibited [3H]MK-801 binding with an IC50 of 0.58 μM and an IC50 of 12.17 μM upon addition of 100 μM spermidine. The increase in IC50 upon addition of spermidine suggests competitive antagonism between the inhibitor and spermidine at the arcaine-sensitive polyamine site of the NMDA receptor complex.
- Sharma, Terre A.,Carr, Andrew J.,Davis, Rebecca S.,Reynolds, Ian J.,Hamilton, Andrew D.
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p. 3459 - 3464
(2007/10/03)
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- Effect of Substituents at the 5-Position on the First and Second Dissociation Constants of Isophthalic Acid
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The dissociation constants of benzoic acid and 20 of its meta- or para-substituted derivatives and of isophthalic acid and ten of its 5-substituted derivatives have been measured in 50 wtpercent aqueous methanol.The Hammett ρ value for benzoic acid is 1.28; for isophthalic acid the ρ values are 1.21 (pK1) and 1.20 (pK2).The ?meta values for hydroxy and acetoxy are -0.01 and +0.29, respectively, in this system.Values for ?meta for CO2H and CO2- are calculated to be +0.28 and -0.20, respectively; however there are indications that these values are not completely structure-independent.
- Gumbley, Stewart J.,Stewart, Ross
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p. 529 - 532
(2007/10/02)
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