Oxime esters as acylating agents in the aminolysis reaction. A simple and chemoselective method for the preparation of amides from amino alcohols
Oxime esters, such as acetone O-alkanoyl-, O-alkenoyl- or O-benzyloxycarbonyloximes, react with amines under extremely mild conditions to give the corresponding amides in very good yield. When amino alcohols are used a total chemoselectivity is observed.
Fernandez,Menendez,Gotor
p. 713 - 716
(2007/10/02)
A USEFUL METHOD FOR SELECTIVE ACYLATION OF ALCOHOLS USING 2,2'-BIPYRIDYL-6-YL CARBOXYLATE AND CESIUM FLUORIDE
Primary and secondary alcohols are acylated under mild conditions by the of use 2,2'-bipyridyl-6-yl carboxylates and cesium fluoride.Furthermore, the reaction is successfully applied to selective acylation of a primary carbinol group of diols containing primary and secondary carbinol groups or exclusive O-acylation of aromatic amino alcohols.