Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones
Context and objective: The present study is to elucidate the comparative inhibition of tetrameric carbonyl reductase (TCBR) activity by alkyl 4-pyridyl ketones, and to characterize its substrate-binding domain. Materials and methods: The inhibitory effect
n-Butyllithium at -78°C readily abstracts the methine proton from the title compound. The anion reacts efficiently with a range of electrophiles to provide 4-pyridyl ketones upon acid hydrolysis.
Hydroacylation of 1-alkene with heteroaromatic aldehyde by Rh(I) and additives
Hydroacylation of 1-alkene with a heteroaromatic aldehyde such as pyridinecarboxaldehyde, thiophenecarboxaldehyde and furfural derivatives under cocatalyst of Wilkinson's complex and 2-amino-3-picoline gave poor yield of hydroacylated product. The addition of a catalytic amount of bis(cyclopentadienyl)zirconium dichloride or bis(cyclopentadienyl)titanium dichloride as an additive dramatically increased the yield of the hydroacylated ketone product.
Jun, Chul-Ho,Lee, Dae-Yon,Hong, Jun-Bae
p. 6673 - 6676
(2007/10/03)
STERIC EFFECTS IN THE REACTION OF DI(BROMOMAGNESIO)ALKANES WITH CARBOXYLIC ESTERS
Largely different product distributions were observed on the action of various carboxylic esters with 1,4-di(bromomagnesio)butane and its homologue 1,5-di(bromomagnesio)pentane.The much larger yields of reduction product with the latter are the evidence for the structural geometric requirements for the annelation step.
Canonne, Persephone,Belanger, Denis,Lemay, Gilles
p. 4995 - 4998
(2007/10/02)
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