- A 3 - (4-hydroxy phenyl) propionamide synthetic method
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The invention discloses a synthesis method of 3-(4-hydroxyphenyl)propanamide. P-hydroxyphenylpropionic acid used as the raw material is subjected to continuous two-step reaction to prepare the 3-(4-hydroxyphenyl)propanamide. The reaction system composed o
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Paragraph 0028 - 0032
(2017/02/24)
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- METHOD OF PRODUCING 3-(4-HYDROXYPHENYL) PROPANOIC ACID AMIDE COMPOUND
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PROBLEM TO BE SOLVED: To provide a method of producing a 3-(4-hydroxyphenyl) propanoic acid amide compound which has excellent productivity, causes little by-product waste, and is inexpensive and ecological. SOLUTION: A method of producing 3-(4-hydroxyphenyl) propanoic acid amide compound represented by the general formula (2) comprises catalytic hydrogenation reduction of a side chain double bond of a p-hydroxycinnamic acid amide compound represented by the general formula (1) (where R is hydrogen, a hydroxy group, or a methoxy group) in the presence of a metal catalyst. COPYRIGHT: (C)2015,JPOandINPIT
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Paragraph 0059-0061
(2018/10/27)
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- Sinapis phylogeny and evolution of glucosinolates and specific nitrile degrading enzymes
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Levels of sinalbin (4-hydroxybenzylglucosinolate) and 28 other glucosinolates were determined in leaves and roots of 20 species that were either phylogenetically close to Sinapis alba, Sinapis arvensis, or Sinapis pubescens (tribe Brassiceae, Brassicaceae), or were expected to contain arylalkyl nitrilase activity. Comparison with a molecular phylogenetic tree based on ITS DNA sequences identified two separate occurrences of sinalbin. The first in a group of species related to S. alba (including members of the genera Coincya and Kremeriella); and the second in S. arvensis, nested among sinalbin deficient species. Significant 4-hydroxyphenylacetonitrile degrading enzyme activity was found in both S. alba and S. arvensis, but in S. alba the major product was the corresponding carboxylic acid, while in S. arvensis the major product was the amide. Both investigated enzyme activities, nitrilase and nitrile hydratase, were specific, accepting only certain arylacetonitriles such as 4-hydroxy and 4-methoxyphenylacetonitrile. Only the S. alba enzyme required an oxygen in para position of the substrate, as found in sinalbin. Indole-3-acetonitrile, arylcyanides, and arylpropionitriles were poor substrates. The nitrilase activity of S. alba was quantitatively comparable to that reported in the monocot Sorghum bicolor (believed to be involved in cyanogenic glycoside metabolism). Glucosinolates derived from methionine were found in all Sinapis clades. Glucosinolate patterns suggested a complex evolution of glucosinolates in the investigated species, with several apparent examples of abrupt changes in glucosinolate profiles including chain length variation and appearance of glucosinolates derived from branched-chain amino acids. NMR data for desulfated homosinalbin, 9-methylsulphonylnonylglucosinolate, 3-methylpentylglucosinolate and related glucosinolates are reported, and a facultative connection between sinalbin and specific nitrilases is suggested.
- Agerbirk, Niels,Warwick, Suzanne I.,Hansen, Paul R.,Olsen, Carl E.
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experimental part
p. 2937 - 2949
(2009/04/10)
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- A METHOD OF MANUFACTURING 3-(4-HYDROXYPHENYL)PROPANOIC ACID AMIDE, ITS APPLICATION IN THE MANUFACTURE OF ANTI-AGING COMPOSITIONS AND AN ANTI-AGING COMPOSITION
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The subjects of the present invention are a method of manufacturing 3-(4-hydroxyphenyl)propanoic acid amide, its application in the manufacture of anti-aging compositions and an anti-aging composition. As phloretamide possesses a series of biological prop
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Page/Page column 7
(2008/06/13)
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- RECEPTOR FUNCTION CONTROLLING AGENT
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The GPR40 receptor function regulator of the present invention, which comprises a compound having an aromatic ring and a group capable of releasing cation is useful as an insulin secretagogue or an agent for the prophylaxis or treatment of diabetes and the like.
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Page/Page column 81
(2008/06/13)
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- Formation of By-products during Sodium-Liquid Ammonia Reduction in Peptide Chemistry
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Reduction of protected model peptides by the usual excess of sodium in liquid ammonia leads to undesired by-products; the generally accepted blue colour for the end point is unnecessary for complete reduction.
- Schoen, Istvan,Szirtes, Tamas,Ueberhardt, Tamas
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p. 639 - 640
(2007/10/02)
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