- PREPARATION OF 4,5-DIALKYL-3-ACYL-PYRROLE-2-CARBOXYLIC ACID DERIVATIVES BY FISCHER-FINK TYPE SYNTHESIS AND SUBSEQUENT ACYLATION
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The present invention relates to an improved synthesis of pyrrole capping group precursors of formula I-a: comprising: combining an aqueous solution of the compound of formula IV-a: wherein R3 is C1-12 aliphatic, C3-12 alkyl-cycloaliphatic, C3-12 alkyl-aryl, C3-12 alkyl-heteroaryl, or C3-12 alkyl-cycloaliphatic; with a compound of formula V-a, wherein R1 and R2 are each independently C1-6 aliphatic; in the presence of zinc, water, and optionally an additional suitable solvent to form a compound of formula VI.
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Page/Page column 24-26
(2008/06/13)
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- Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
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The present invention relates to compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antivi
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