- 3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF
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The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx, X1, X2, and R1 are as defined herein, and methods of making and using same.
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Paragraph 1803; 1805
(2020/02/05)
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- METHOD FOR PRODUCING GLYCOL FROM OXIRANE COMPOUND
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The objective of the present invention is to provide a method for the highly selective production of dipropylene glycol containing 1,1'-oxybis-2-propanol in a proportion of 0.10 to 0.70 and/or tripropylene glycol containing 1,1'-[(1-methyl-1,2-ethanediyl)bis(oxy)]bis-2-propanol in a proportion of 0.10 to 0.70. The present invention is a method for producing dipropylene glycol containing 1,1'-oxybis-2-propanol in a proportion of 0.10 to 0.70 and/or tripropylene glycol containing 1,1'-[(1-methyl-1,2-ethanediyl)bis(oxy)]bis-2-propanol in a proportion of 0.10 to 0.70, the method comprising a reaction step of making a reactant comprising propylene oxide and water react in the presence of a catalyst, wherein the catalyst comprises at least one element selected from the group consisting of vanadium, niobium, and tantalum, and the Hammett acidity function (H) of the catalyst satisfies H ≤ 9.3.
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Paragraph 0061; 0066; 0076
(2014/10/29)
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- AQUEOUS PIGMENT DISPERSION CONTAINING LOW MOLECULAR WEIGHT POLYTRIMETHYLENE ETHER GLYCOL
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The present disclosure is directed to an aqueous pigment dispersion comprising low molecular weight polytrimethylene ether glycol. This disclosure is further directed to an antimicrobial aqueous pigment dispersion comprising the low molecular weight polytrimethylene ether glycol. The pigment dispersion can be used in coating compositions as interior and exterior top coats, basecoats, primers, primer surfacers and primer fillers. The disclosure is particularly directed to an aqueous pigment dispersion comprising components derived from renewable resources.
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Page/Page column 18-19
(2013/03/26)
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- ANTIMICROBIAL COMPOSITIONS COMPRISING TRIMETHYLENE GLYCOL OLIGOMER AND METHODS OF USING THE COMPOSITIONS
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Disclosed are antimicrobial compositions, and methods for killing, inhibiting, or preventing the growth of microbes, using trimethylene glycol oligomers or dimers. The trimethylene glycol oligomers and dimers have the formula R(CH2CH2CH2—O—CH2CH2CH2)nR1 where R and R1 are hydroxyl, amine, or ester functionalitiess, and n is 2 or higher. The antimicrobial compositions are useful in personal care and cosmetic compositions
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Page/Page column 7
(2011/10/04)
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- AZOLE DERIVATIVES AS WTN PATHWAY INHIBITORS
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The present invention relates to new compounds of formula I, to processes for their preparation, to pharmaceutical formulations containing such compounds and to their use in therapy. Such compounds find particular use in the treatment and/or prevention of conditions or diseases which are affected by over-activation of signaling in the Wnt pathway. For example, these may be used in preventing and/or retarding proliferation of tumor cells, for example carcinomas such as colon carcinomas.
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Page/Page column 109-110
(2010/12/29)
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- ETHER COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
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The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
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Page/Page column 232
(2010/02/13)
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- Method for removal of MW176 cyclic acetal formed during the production of 1,3-propanediol
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The present invention is an improvement upon the process for the production of 1,3-propanediol (PDO) wherein an aqueous solution of 3-hydroxypropanal (HPA) is formed, and the HPA is subjected to hydrogenation to produce a crude PDO mixture comprising PDO, water, MW176 acetal, and high and low volatility materials, wherein the crude PDO mixture is dried to produce a first overhead stream comprising water and some high volatility materials and a dried crude PDO mixture as a first distillate bottoms stream comprising PDO, MW176 acetal, and low volatility materials, and wherein the dried crude PDO mixture is distilled to produce a second overhead stream comprising some high volatility materials, a middle stream comprising PDO and MW176 acetal, and a second distillate bottoms stream comprising PDO and low volatility materials. The improvement on this process comprises treating the crude PDO mixture and/or the dried crude PDO mixture and/or the PDO product with an acidic zeolite, an acid form cation exchange resin, or a soluble acid to convert the MW176 cyclic acetal to more volatile materials which can be easily separated from PDO by distillation.
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- Solid acid catalyzed reactive stripping of impurities formed during the production of 1, 3-propanediol
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A process for producing 1,3-propanediol comprising the steps of: a) forming an aqueous solution of 3-hydroxypropanal, b) hydrogenating the 3-hydroxypropanal to form a first crude 1,3-propanediol mixture comprising 1,3-propanediol, water, and MW 132 cyclic acetal, c) distilling the first crude 1,3-propanediol mixture to remove water and low boiling impurities and form a second crude 1,3-propanediol mixture, d) contacting the second crude 1,3-propanediol mixture with a solid acid purifier at a temperature of from about 50 to about 250° C. to convert the MW 132 cyclic acetal to more volatile cyclic acetals, and e) separating the more volatile cyclic acetals from the 1,3-propanediol by distillation or gas stripping.
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- Preparation of Discrete Oligoethers: Synthesis of Pentabutylene Glycol and Hexapropylene Glycol by Two Complementary Methods
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Two experimentally facile methods for the preparation of discrete oligoethers are reported. The first involves an iterative sequence of oxidation, acetal formation, and reductive ring opening for the synthesis of penta-1,4-butylene glycol. The second method is also iterative, comprising phase-transfer etherification and end-group deprotection to form hexa-1,3-propylene glycol. These methods offer significantly improved yields and purification protocols over previously reported syntheses.
- Knuf, Erin C.,Jiang, Jian-Kang,Gin, Mary S.
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p. 9166 - 9169
(2007/10/03)
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- Solid state stereochemistry of crown ethers: X-ray crystal structure and 13C NMR studies of the LiNCS complex of 1,4,7,11-tetraoxacyclotetradecane
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The title complex is asymmetric in the crystal due to the spatial orientation of the NCS function. The space group has been determined to be P21 with a = 9.496(3), b = 8.736(3), c = 9.676(3) A, β = 117.859(5)°, and Z = 2. The solid state 13C NMR spectrum is consistent with the lack of symmetry in the crystal and there is little evidence for large amplitude motion in the macrocycle as determined from the dipolar dephased spectrum.
- Buchanan,Driega,Yap
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p. 316 - 321
(2007/10/03)
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- Transformation of 1,3-, 1,4- and 1,5-diols over perfluorinated resinsulfonic acid (Nafion-H)
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The transformations of 1,3-, 1,4- and 1,5-diols over perfluorinated resinsulfonic acids (Nafion-H) were studied and correlations were examined between the structure of the investigated diols, the possible transformation directions and the catalytic properties of Nafion-H. Comparisons were also made between the catalytic properties of Nafion-H and zeolites. The characteristic transformations of 1,3-diols depend on their structure. 1,3-Propanediol undergoes dehydration via 1,2-elimination and yields oligomers via intermolecular dehydration. 1,3-Diols with an alkyl substituent on the carbon between those bearing the OH groups undergo 1,2-elimination yielding unsaturated alcohols and dienes, and give carbonyl compounds via the loss of water and hydride shifts analogous to the pinacol rearrangement. The strong acidity of Nafion-H and the lack of strong basic sites are advantageous for the latter reaction. 1,3-Diols with two substituents at this position mainly yield fragmentation products. Stereoselective cyclodehydration to the corresponding oxacycloalkanes is the characteristic transformation of 1,4- and 1,5-diols over Nafion-H.
- Bucsi,Molnar,Bartok,Olah
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p. 3319 - 3326
(2007/10/02)
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- Organotin-containing composition for the stabilization of polymers of vinyl chloride
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An organotin-containing composition for the stabilization of polymers or copolymers of vinyl chloride in which there is incorporated a stabilizing amount of an organotin compound containing at least two tin atoms and which is a mercapto, hydroxy or alkoxy substituted ester of a mercapto acid substituted organotin mercapto acid diester.
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- Binding and Transport of Alkali Metal Ions by Synthetic Analogoues of Nactins
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Our new synthesis of 32-linked macrocycles, models of nactin ionophores, has been extended to more complex structures.The complexation properties of these macrocycles were determined using the method of extraction of alkali metals from an aqueous phase.Extraction constants of some compounds are much higher than those measured for nonactin and for dibenzo-18-crown-6, whereas the association constants measured for the same alkali metals are very weak.There is no complexation selectivity towards the cations, only a slight preference for lithium is observed.These synthetic ionophores are able to transport alakli metal ions through a non-polar barrier, but without clear selectivity.The measured rates are lower than those obtained for nonactin and dibenzo-18-crown-6, the decomplexation being the rate-determining step.
- Samat, Andre,Bibout, Mohammed El Malouli,Elguero, Jose
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p. 1717 - 1724
(2007/10/02)
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- Ditertiary diamine compounds
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The preparation of ditertiary aliphatic diamines 3 designed as drugs protecting CNS acetylcholinesterase against organophosphate inhibition, is described. Owing to the radicals at the basic nitrogen atoms, these compounds should exist in appreciable amounts both as base and as diammonium ion at biological pH's.
- Schnekenburger
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p. 1853 - 1858
(2007/10/05)
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