- Catalytic Regio- and Enantioselective Oxytrifluoromethylthiolation of Aliphatic Internal Alkenes by Neighboring Group Assistance
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Chiral selenide-catalyzed oxytrifluoromethylthiolation of aliphatic internal alkenes by a formally intermolecular strategy is disclosed, affording CF3S 1,3-amino alcohol and 1,3-diol derivatives with high regio-, enantio-, and diastereoselectivities. The reactions are promoted by a neighboring imide or ester group on substrates via a six-membered ring transition state. This assistance strategy is also successfully applied to the regio- and diastereoselective oxyhalofunctionalization of internal alkenes and the conversion of alkynes.
- Xu, Jia,Zhang, Yuanyuan,Qin, Tian,Zhao, Xiaodan
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supporting information
p. 6384 - 6388
(2018/10/09)
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- REDUCTION OF CONJUGATED DIENOIC CARBOXYLIC ACIDS AND ESTERS WITH SODIUM DITHIONITE
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Reduction of 2,4-alkadienoic acids and esters with sodium dithionite was carried out in aqueous solution or under PTC conditions to give, almost excusively, Z:E isomeric mixtures of the corresponding 3-alkenoic acids and esters, respectively, in good yields.
- Camps, Francisco,Coll, Jose,Guerrero, Angel,Guitart, Josefa,Riba, Magi
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p. 715 - 718
(2007/10/02)
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