- Ultrasensitive (Co)polymers based on poly(methacrylamide) structure with fining-tunable pH responsive value
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Novel pH responsive copolymers with tertiary amine groups were prepared by free radical polymerization with 2-(dialkylamino)ethyl methacrylate monomers. These polymers were pH sensitive with the ability to be responsively fine-tuned in aqueous solution, which was proven through titration, transmittance measurements, and proton nuclear magnetic resonance spectroscopy. The polymers were soluble in water at low pH values, induced by electrostatic repulsion between amine groups, and aggregated above their pKa value due to the hydrophobic effect of the alkyls. The pH responsive values were precisely tuned from 7.4 to 4.8 by increasing the hydrophobic monomer ratio. Our work provides a novel approach for the development of ultrasensitive pH-responsive polymers for application in biomedical materials.
- Fan, Haiming,Li, Po,Li, Wei,Li, Hui,Huang, Xiaonan
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- PH RESPONSIVE COMPOSITIONS, FORMULATIONS, AND METHODS OF IMAGING A TUMOR
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Described herein are formulations, methods, and pH responsive compositions useful for the detection of primary and metastatic tumor tissues.
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Paragraph 00170;00173; 00175; 00179
(2021/05/29)
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- PH RESPONSIVE BLOCK COPOLYMER COMPOSITIONS AND MICELLES THAT INHIBIT MCT 1 AND RELATED PROTEINS
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Described herein are therapeutic pH responsive compositions comprising a block copolymer and a therapeutic agent useful for the treatment of cancer.
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Paragraph 00137; 00141-00142
(2021/10/30)
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- N, N-Dimethyl-Substituted Boron Ketoiminates for Multicolor Fluorescent Initiators and Polymers
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In this contribution, an efficient synthesis strategy of multicolor fluorescent N,N-dimethyl-substituted boron ketoiminates (NBKI) was presented. The introduction of dimethylamino group as donor and NOBF2 moiety as acceptor with variously tunable substituents led to the formation of D (donor)-π-A (acceptor) system in NBKI molecules, which exhibited a high fluorescence efficiency and a significant red shift of absorption/emission in solution. NBKI molecules were applied in the synthesis of multicolor fluorescent ATRP initiators (i-NBKI 1-4) and RAFT initiator (i-NBKI 5), as well as multicolor fluorescent PS, PMMA, PDBA, or PEG-based homopolymers/copolymers. It was demonstrated that PEG-based polymers showed effective fluorescence emission, good water solubility, and great potential in biological applications. This work bridges the gap in current organoboron compounds and multicolor fluorescent polymerization initiators and related fluorescent polymers/copolymers by utilizing D-π-A design. It may shed light on the downstream applications in next-generation multicolor fluorescent probes/devices.
- Yang, Dong,Liu, Pei,Bai, Ting,Kong, Jie
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p. 3339 - 3348
(2020/04/20)
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- (Meth) acrylic acid ester manufacturing method of N, N-substituted amino alcohol
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The present invention relates to a process for preparing (meth)acrylic esters (F) of N,N-substituted amino alcohols, by transesterifying N,N-substituted amino alcohols (I) in which Y and Z are each independently C1-C20-alkyl, C3-C15-cycloalkyl, aryl, or Y and Z together with the nitrogen atom connecting them form a 5- to 9-membered saturated heterocyclic radical which optionally has oxygen, sulfur, nitrogen or C1-C4-alkyl-substituted nitrogen as a further heteroatom, and X is C2-C20-alkylene which may be interrupted by 1 to 10 nonadjacent oxy groups and/or unsubstituted or methoxy-substituted C1-C4-alkylimino groups, or C3-C15-cycloalkylene, with at least one (meth)acrylic ester (D) in the presence of at least one heterogeneous catalyst (K), wherein the heterogeneous catalyst (K) is used without any further solvent and the content of polymerization inhibitors in the reaction mixture is 450 ppm, and to the use of the (meth)acrylic esters (F) of N,N-substituted amino alcohols.
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Paragraph 0084-0086
(2017/02/23)
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- PROCESS FOR PREPARING (METH)ACRYLIC ESTERS OF N,N-SUBSTITUTED AMINO ALCOHOLS
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The present invention relates to a process for preparing (meth)acrylic esters (F) of N,N-substituted amino alcohols, by transesterifying N,N-substituted amino alcohols (I) in which Y and Z are each independently C1-C20-alkyl, C3-C15-cycloalkyl, aryl, or Y and Z together with the nitrogen atom connecting them form a 5- to 9-membered saturated heterocyclic radical which optionally has oxygen, sulfur, nitrogen or C1-C4-alkyl-substituted nitrogen as a further heteroatom, and X is C2-C20-alkylene which may be interrupted by 1 to 10 nonadjacent oxy groups and/or unsubstituted or methoxy-substituted C1-C4-alkylimino groups, or a C3-C15-cycloalkylene, with at least one (meth)acrylic ester (D) in the presence of at least one heterogeneous catalyst (K), wherein the heterogeneous catalyst (K) is used without any further solvent and the content of polymerization inhibitors in the reaction mixture is 450 ppm, and to the use of the (meth)acrylic esters (F) of N,N-substituted amino alcohols.
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Page/Page column 5
(2012/04/05)
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- CROSSLINKABLE SYRUP COPOLYMERS WITH AMINOALKYL (METH)ACRYLOYL SOLVENT MONOMERS
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A pre-adhesive syrup polymer composition is described comprising an acid-functional (meth)acrylate copolymer and an aminoalkyl (meth)acryloyl solvent monomer, which when polymerized, provides a pressure-sensitive adhesive and pressure-sensitive adhesive articles.
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Page/Page column 8
(2012/10/08)
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- Tunable, ultrasensitive pH-responsive nanoparticles targeting specific endocytic organelles in living cells
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Switch it up: Tunable, pH-responsive nanoparticles can be selectively activated in different endocytic compartments. At high pHvalues, micelle formation (see picture, left) quenches fluorescence by Foerster resonance energy transfer. The micelles disassemble at low pHvalues, leading to fluorescence emission. This nonlinear on/off nanoplatform offers many exciting opportunities in diagnostic imaging and drug-delivery applications. Copyright
- Zhou, Kejin,Wang, Yiguang,Huang, Xiaonan,Luby-Phelps, Katherine,Sumer, Baran D.,Gao, Jinming
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supporting information; experimental part
p. 6109 - 6114
(2011/09/12)
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