Mechanistic Studies on Thiazolidine Formation in Aldehyde/Cysteamine Model Systems
A mechanism was proposed to elucidate the formation of a thiazolidine in aldehyde/cysteamine model systems. Buffer dramatically promotes thiazolidine formation from formaldehyde and cysteamine. Phosphate tends to stabilize the primary carbocation formed, and this may lead to completion of the cyclization by attack of the amino nitrogen on the activated carbon. Protic solvent, by removing the water molecule, further enhances thiazolidine formation. Redox reaction catalyzed by phosphate ions results in the conversion of thiazolidine to the corresponding thiazoline through hydride transfer.
Huang, Tzou-Chi,Huang, Lee-Zen,Ho, Chi-Tang
p. 224 - 227
(2007/10/03)
Determination of Physical and Spectral Data on Thiazolidines for Trace Aldehyde Analysis
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Yasuhara, Akio,Shibamoto, Takayuki
p. 2273 - 2274
(2007/10/02)
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