- Efforts toward the synthesis of (+)-Lyconadin A
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Abstract: Synthetic efforts toward the synthesis of (+)-lyconadin A are described. B-Alkyl Suzuki coupling is utilized for combining 2-iodo cyclohexenone with the piperidine subunit. The piperidine subunit is derived from 5-bromo-3-nicotinic acid, and iod
- Karella, Satish,Raghavan, Sadagopan
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- Facile synthesis of peptide-porphyrin conjugates: Towards artificial catalase
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A facile synthetic method for peptide-porphyrin conjugates containing four peptide units on one porphyrin was developed using chemoselective reactions. The key building blocks, 5,10,15,20-tetrakis(3-azidophenyl)porphyrin 1 and 5,10,15,20-tetrakis(5-azido-3-pyridyl)porphyrin 2, were efficiently synthesized and used as substrates for two well-known chemoselective reactions, traceless Staudinger ligation and copper-catalyzed azide alkyne cycloaddition (so-called click chemistry). Both reactions gave the desired compounds, and click chemistry was superior for our purpose. To confirm the value of the established methodology, nine peptide-porphyrin conjugates were synthesized, and their catalase- and peroxidase-like activity in water was evaluated. Our synthetic strategy is expected to be valuable for the preparation of artificial heme protein models.
- Umezawa, Naoki,Matsumoto, Nobuyoshi,Iwama, Shinsuke,Kato, Nobuki,Higuchi, Tsunehiko
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experimental part
p. 6340 - 6350
(2010/10/04)
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- AZOLECARBOXAMIDE HERBICIDES
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Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful for controlling undesired vegetation, wherein J is (J-1), (J-2,(J-3), (J-4), (J-5), (J-6), (J-7), (J-8) and R1a, R1b, R1c, R2a, R2b, R3, R4, R05, T, U, W, Y and Z are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling undesired vegetation which involves contacting the vegetation or its environment with an effective amount of a compound of Formula (I). Also disclosed are mixtures and compositions comprising a herbicidally effective amount of a compound of Formula (Iz) wherein J, R1a, R1b, R1c, R2a, R2b, R3, R4, R05, T, U, W, Y and Z are as defined in the disclosure; and an effective amount of another herbicide or herbicide safener. Also disclosed is a method for selectively controlling undesired vegetation in a crop that involves contacting the locus of a crop with an effective amount of a compound of Formula (Iz) and a effective amount of a safener.
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- PYRROLE COMPOUNDS FOR THE TREATMENT OF PROSTAGLANDIN MEDIATED DISEASES
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Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine, in particular their use in the treatment of prostaglandin mediated diseases such as pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.
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- Stereoelectronic substituent effects in polyhydroxylated piperidines and hexahydropyridazines
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From the pKa values of the conjugate acids of a large series of hydroxylated piperidines and hexahydropyridazines, a consistent difference in basicity was found between stereo-isomers having an axial or equatorial hydroxyl (OH) group either β o
- Jensen, Henrik Helligso,Lyngbye, Laila,Jensen, Astrid,Bols, Mikael
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p. 1218 - 1226
(2007/10/03)
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- Syntheses of Some Aminopiperidinecarboxylic Acids Related to Nipecotic Acid
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This paper describes the syntheses of (3RS,5SR)-5-hydroxypiperidine-3-carboxylic acid (8), (3RS,5SR)-5-aminoperidine-3-carboxylic acid (9), (RS)-3-hydroxypiperidine-3-carboxylic acid (13), (RS)-α-amino-3-pyridineacetic acid (18), and α-amino-3-piperidineacetic acid (19), compound 19 probably being a mixture of diastereomeric racemates.The compounds 8 and 9 were prepared from 5-aminonicotinic acid by catalytic hydrogenation.The relative stereochemistry of 9 was established by 270 MHz 1H NMR spectroscopy.The α-hydroxy acid 13 was prepared via cyanhydrin reaction of the 3-piperidone derivative 11.The α-amino acids 18 and 19 were prepared from 3-pyridineacetic acid by nitrosation and subsequent catalytic hydrogenation.
- Jacobsen, Poul,Schaumburg, Kjeld,Larsen, Jens-Joergen,Krogsgaard-Larsen, Povl
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p. 289 - 294
(2011/02/21)
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