- Ruthenium-catalysed hydroxycarbonylation of olefins
-
State-of-the-art catalyst systems for hydroxy- and alkoxycarbonylations of olefins make use of palladium complexes. In this work, we report a complementary ruthenium-catalysed hydroxycarbonylation of olefins applying an inexpensive Ru-precursor (Ru3(CO)12) and PCy3as a ligand. Crucial for the success of this transformation is the use of hexafluoroisopropanol (HFIP) as the solvent in the presence of an acid co-catalyst (PTSA). Overall, moderate to good yields are obtained using aliphatic olefins including the industrially relevant substrate di-isobutene. This atom-efficient catalytic transformation provides straightforward access to various carboxylic acids from unfunctionalized olefins.
- Dühren, Ricarda,Kucmierczyk, Peter,Jackstell, Ralf,Franke, Robert,Beller, Matthias
-
p. 2026 - 2030
(2021/04/09)
-
- A photocleavable masked nuclear-receptor ligand enables temporal control of C.elegans development
-
The development and lifespan of C.elegans are controlled by the nuclear hormone receptor DAF-12, an important model for the vertebrate vitaminD and liverX receptors. As with its mammalian homologues, DAF-12 function is regulated by bile acid-like steroidal ligands; however, tools for investigating their biosynthesis and function invivo are lacking. A flexible synthesis for DAF-12 ligands and masked ligand derivatives that enable precise temporal control of DAF-12 function was developed. For ligand masking, photocleavable amides of 5-methoxy-N-methyl-2-nitroaniline (MMNA) were introduced. MMNA-masked ligands are bioavailable and after incorporation into the worm, brief UV irradiation can be used to trigger the expression of DAF-12 target genes and initiate development from dauer larvae into adults. The invivo release of DAF-12 ligands and other small-molecule signals by using photocleavable MMNA-masked ligands will enable functional studies with precise spatial and temporal resolution. Copyright
- Judkins, Joshua C.,Mahanti, Parag,Hoffman, Jacob B.,Yim, Isaiah,Antebi, Adam,Schroeder, Frank C.
-
supporting information
p. 2110 - 2113
(2014/03/21)
-
- ALPHA-BRANCHED ALKENOIC ACIDS AND THE USE OF ALPHA-BRANCHED ALKANOIC AND ALKENOIC ACIDS AS A FRAGRANCE
-
The present invention refers to alpha branched alkanoic and alkenoic acids of formula (I) wherein X and R have the same meaning as given in the description. The invention further refers to perfume compositions and fragrance applications comprising them.
- -
-
Page/Page column 5-6
(2010/06/20)
-
- PRODUCTION OF METHYL 2-METHYLENE-5,10-UNDECADIENOATE FROM BUTADIENE AND METHYL METHACRYLATE AT A HOMOGENEOUS COMPLEX NICKEL CATALYST AND SOME OF ITS TRANSFORMATIONS
-
A method was developed for the production of methyl 2-methylene-5,10-undecadienoate from butadiene and methyl methacrylate at a homogeneous complex nickel catalyst.Methyl 1,6-trans-9-cis/trans,13-trans,18-nonadecapentaene-10-carboxylate is formed as side product. 2-Methylundecanal (having a fragrant odor), 2-methyl-1-undecanol, 2-nonyl-1-undecanol, and 2-methylene-5,10-undecadienoic acid, which have found use in the formulation of medicinal products, were obtained from these esters by various transformations.
- Zakharkin, L. I.,Guseva, V. V.,Kamernitskii, D. A.
-
p. 1056 - 1059
(2007/10/02)
-
- Hydrocarboxylation of unsaturated carboxylic acids to linear dicarboxylic acids
-
The preparation of linear dicarboxylic acids, e.g., adipic acid, by hydrocarboxylating unsaturated monocarboxylic acids, e.g., 3-pentenoic acid, with carbon monoxide and water in the presence of a rhodium-containing catalyst, an iodide promoter and certain inert halocarbon solvents, e.g., methylene chloride.
- -
-
-