A novel and convenient synthesis of 3-amino-2H-1,2,4-triazoles from isoselenocyanates and hydrazine hydrate
A novel and convenient one-pot synthesis of 3-amino-2H-1,2,4-triazoles from two molecules of isoselenocyanates and hydrazine hydrate via cyclodeselenisation was developed. Various 3-amino-2H-1,2,4-triazoles were obtained in moderate to good yields (33-45%
Cycloaddition of synthetic equivalent of nonstabilized aminonitrile ylides: A new route to amino-substituted aΔ2-imidazolines and Δ3-1,2,4-triazolines
The N-unsubstituted nonstabilized azomethine ylides generated from the desilylation of N-[(trimethylsilyl)methyl]iminium triflates undergo successful cycloaddition to strongly polarized sulfonylimines and diethyl azodicarboxylate to produce the corresponding Δ2-imidazolines and Δ3-1,2,4-triazolines together with the initial cycloadducts. The initial cycloadducts are converted to the corresponding aminonitrile ylide cycloadducts. Thus the present process provides a new route to amino-substituted Δ2-imidazolines and Δ3-1,2,4-triazolines that are otherwise relatively inaccessible.