- High-efficiency low-pollution preparation method for progesterone
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The invention discloses a high-efficiency low-pollution preparation method of progesterone, and belongs to the technical fields of preparation and processing of steroid hormone drugs. According to themethod, 21-hydroxy-20-methylpregn-4-en-3-one is used as a starting raw material, a TEMPO-NaClO reagent is used for oxidation to form an aldehyde, enamination is performed, and copper catalytic oxidation degradation is performed to prepare the progesterone. The preparation method of the progesterone provided by the invention has the advantages that the raw materials and reagents are cheap and easyto obtain, and the market competitiveness in equipment investment and production cost is extremely high; the reaction is mild and safe, and the operation is easy to control; the reaction yield is high, and purification is simple and convenient; and the used reagents are low in environmental pollution, particularly chromium-containing high-pollution reagents are not used, so that the method conforms to the industrial development trend of green chemistry and has good economic and social benefits.
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Paragraph 0014; 0039-0040
(2019/11/21)
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