- GGA DERIVATIVES
-
This invention relates to geranylgeranyl acetone (GGA) derivatives, pharmaceutical compositions comprising GGA derivatives and the use of GGA derivatives.
- -
-
Paragraph 0351; 0354
(2015/05/26)
-
- METHODS FOR TREATING NEURON DAMAGE
-
This invention relates to the use of geranylgeranyl acetone (GGA), its isomers, and GGA derivatives in a method for for treating a disease in a subject mediated in part by miRNA-378 or miRNA-711 increased activity comprising administering to the subject a therapeutically effective amount of 5-trans-GGA or a derivative thereof.
- -
-
Paragraph 0304
(2014/07/22)
-
- GGA AND GGA DERIVATIVES COMPOSITIONS THEREOF AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES INCLUDING PARALYSIS INCLUDING THEM
-
This invention relates to geranylgeranyl acetone (GGA) derivatives and the use of GGA, its isomers, and GGA derivatives in methods for inhibiting neural death, increasing neural activity, increasing axon growth and cell viability, and increasing the survival rate of subjects administered the GGA or GGA derivatives.
- -
-
Paragraph 0292
(2014/10/18)
-
- GGA AND GGA DERIVATIVES, COMPOSITIONS THEREOF AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES INCLUDING PARALYSIS INCLUDING THEM
-
This invention relates to geranylgeranyl acetone (GGA) derivatives and the use of GGA, its isomers, and GGA derivatives in methods for inhibiting neural death, increasing neural activity, increasing axon growth and cell viability, and increasing the survival rate of subjects administered the GGA or GGA derivatives.
- -
-
Paragraph 0277; 0280
(2013/09/12)
-
- METHODS FOR TREATING NEURODEGENERATIVE DISEASES
-
This invention relates to the 5-cis and 5-trans isomers of geranylgeranyl acetone, preferably such synthetic isomers, and pharmaceutical compositions containing such isomers. Other aspects of this invention relate to the use of geranylgeranyl acetone and its isomers in methods for inhibiting neural death, increasing neural activity, and increasing axon growth and cell viability. Geranylgeranyl acetone is a known anti-ulcer drug used commercially and in clinical situations. GGA has also been shown to exert cytoprotective effects on a variety of organs, such as the eye, brain, and heart.
- -
-
Page/Page column 38-39
(2012/03/26)
-
- Synthesis of labelled [13C6]testosterone and [13C5]19-nortestosterone
-
The condensation of ethyl acetoacetate-13C4 and ethyl bromoacetate-13C2 afforded, in seven steps, (1,2,3,4,5-13C5) 5-(diethylphosphono)-2-pentanone ethylene ketal 9. The reaction of this labelled compound with 7-[[(1,1-dimethylethyl)-dimethylsilyl]oxy]-1,6,6a,7,8, 9, 9a, 9b-octahydro-6a-methyl-[6aS-(6aa,7a,9aβ,9ba)] cyclopenta[f][1]benzopyran-3 (2H)-one 13 gave the benzindenone 14 which was converted to (1,2,3,4,10,19-13C6)testosterone 17 then, into (1,2,3,4,10-13C5)19-nortestosterone 18 by a reductive alkylation method.
- Joubert,Beney,Marsura,Luu-Duc
-
p. 745 - 754
(2007/10/02)
-
- INSECT PHEROMONES AND THEIR ANALOGS. XLVII. SYNTHESIS OF 11-OXODODECA-3,6-DIYNOIC ACID - THE ACYCLIC PRECURSOR OF A MACROLIDE COMPONENT OF PHEROMONES OF Oryzaephilus mercator AND O. surinamensis
-
A new approach is proposed to the synthesis of 11-oxododeca-3,6-diynoic acid - the acyclic precursor of a macrolide component of pheromones of Oryzaephilus mercator and O. surinamensis - from the readily available tetrahydropyran or allylacetone via the intermediate 5-bromo-2,2-ethylenedioxypentane.
- Odinokov, V. N.,Ishmuratov, G. Yu.,Kharisova, R. Ya.,Vakhidov, R. R.,Botsman, L. P.,Tolstikov, G. A.
-
p. 240 - 244
(2007/10/02)
-
- Convenient Synthetic Route tp 6,8-Dioxabicyclooctanes, the Aggregation Pheromone Components of Bark Beetles
-
Convenient syntheses of (+/-)-frontalin (I) and (+/-)-brevicomins (IIa) and (IIb) were achieved from pent-4-en-1-ol (2) and pent-4-yn-1-ol (3).In a few simple and unambiguous steps, the alkenol (2) and the alkynol (3) were transformed into the acetal bromide (7) and the alkenyl bromides (14) and (17), respectively.Acylation of Grignard reagents of these bromides provided the corresponding methyl ketones (8), (15), and (18), the key intermediates for the synthesis of the title bicyclic acetals.The ketone (8) was converted into the olefin (9) which, on epoxidation followed by acid hydrolysis, yielded (+/-)-frontalin, whereas epoxidation of the alkenones (15) and (18) and subsequent cyclization afforded exo- and endo-brevicomin, stereoselectively.
- Joshi, Navalkishore N.,Mamdapur, Vasant R.,Chadha, Mohindra S.
-
p. 2963 - 2966
(2007/10/02)
-