cas 24463-15-8, 1-Pyrenemethanol | Articles data

Articles about 24463-15-8Total 7 be found

A pillararene-based ternary drug-delivery system with photocontrolled anticancer drug release
A study was conducted to report a supramolecular system that met these design criteria. Specifically, a photodegradable anticancer prodrug ( Py-Cbl ) containing the anticancer drug chlorambucil and fluorophore pyrene was designed and synthesized. The photo-cleavable group here performed two important functions, such as providing photoresponsive control over the drug release and serving as a linker between the fluorophore and the drug. The absorption and emission spectra of Py-Cbl were first investigated by using UV and fluorescence spectroscopy. The band at 340 nm corresponding to Py-Cbl was similar to that of PyOH in water.
Yu, Guocan,Yu, Wei,Mao, Zhengwei,Gao, Changyou,Huang, Feihe
p. 919 - 925
(2015)
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Selenium Blue-α and -β: Turning on the fluorescence of a pyrenyl fluorophore via oxidative cleavage of the Se-C bond by reactive oxygen species
Rapid oxidation of nonfluorescent pyrenyl-CH2SeAr (Ar = o-nitrophenyl) by hypochlorite yielded pyrenyl-CH2Cl and pyrenyl-CH2OH and turns on blue fluorescence, while slow oxidation of pyrenyl-CH2SeAr with excess
Chen, Wei,Bay, Wan Ping,Wong, Ming Wah,Huang, Dejian
p. 3843 - 3846
(2012/08/13)

Competitive occurrence of homolytic N-O and heterolytic C-O bond cleavage in excited-state 1-(arylmethyloxy)-2-pyridones
The irradiation at 340 nm of the title compounds having 9-anthryl and pyren-1-yl groups in methanol was found to give the heterolytic C-O bond cleavage products: 1-hydroxy-2-pyridone and aryl-substituted dimethyl ether (which predominate for the reaction of the former title compound) in addition to 2-pyridone, aryl-substituted methanol and aryl-substituted formaldehyde derived from the homolysis of the N-O bond (which mainly occurs in the photolysis of the latter title compound). It was also found that substitution of the methyl group for hydrogen at the 6-position of the pyridone skeleton in 1-(9-anthrylmethyloxy)-2-pyridone decreases the relative composition of the arylsubstituted dimethyl ether to some extent. These substituent effects on the product compositions were explained in terms of stereoelectronic effects on a charge transfer-type interaction between the aromatic and pyridone rings in the singlet excited state. Analyses of the ground-state conformation for the title compounds by MM2 calculations and 1H NMR spectroscopy, as well as of their singlet excited-state behaviour, substantiated the existence of a non-emissive intramolecular exciplex intermediate which plays a key role in inducing the C-O bond heterolysis.
Yoshioka, Nariyoshi,Andoh, Chihei,Kubo, Kanji,Igarashi, Tetsutaro,Sakurai, Tadamitsu
p. 1927 - 1932
(2007/10/03)

Anthraquinon-2-ylmethoxycarbonyl (Aqmoc): A new photochemically removable protecting group for alcohols
(formula presented) Synthesis and photochemistry of a new photochemically removable protecting group for alcohols is described. Four carbonates of galactose derivatives (1-4) were synthesized from the corresponding arylmethanols via 4-nitrophenyl carbonate intermediates. Among them, photolysis of anthraquinon-2-ylmethoxycarbonyl (Aqmoc) galactose (1) proceeded with overall photolysis efficiency of 150 (quantum yield 0.10, and molar absorptivity 1500 M-1 cm-1) and rate constant of ～106 s-1. To demonstrate its application to a biologically related molecule, 5′-Aqmoc-adenosine (5) was synthesized and photolyzed to yield adenosine in 91% yield.
Furuta, Toshiaki,Hirayama, Yuuki,Iwamura, Michiko
p. 1809 - 1812
(2007/10/03)

Photoinduced heterolysis of the carbon-oxygen bond in bichromophoric 1- arylmethyloxy-2-pyridones
Irradiation of the title compound having a 9-anthryl (1a) or a 1- pyrenyl group (1b) in methanol was found to give the heterolytic C-O bond cleavage products: 1-hydroxy-2-pyridone and arylmethyl methyl ether, (which predominate for the reaction of 1a), along with 2-pyridone, aryl-substituted methanol and aryl aldehyde derived from the homolysis of the N-O bond (that mainly occurs in the photolysis of 1b). Spectroscopic analysis of the ground- state and excited singlet-state behavior of 1 revealed that a non-emissive intramolecular exciplex (whose formation rate is much faster in 1a than in 1b) plays a key role in inducing the C-O bond heterolysis.
Sakurai, Tadamitsu,Kubo, Kanji,Kojima, Shunsuke,Shoro, Takuya,Inoue, Hiroyasu
p. 9747 - 9750
(2007/10/03)

(1-PYRENYL)METHYL CARBAMATES FOR FLUORESCENT "CAGED" AMINO ACIDS AND PEPTIDES
A highly fluorescent 1-pyrenylmethyloxycarbonyl amino acid (Pmoc-amino acid) is obtained in moderate yield by the reaction of (1-pyrenylmethyl)-4-nitrophenylcarbonate with an amino acid in the presence of sodium carbonate.The condensation of Pmoc-amino acid with an amino acid gives Pmoc-peptide in the presence of 1-ethyl-3-(3-dimethylaminepropyl)carbodiimide and 1-hydroxybenzotriazole.The amino acid is recovered from an H2O-dioxane (2:3) solution of Pmoc-amino acid by irradiation through a Pyrex filter with a medium pressure Hg lamp or at 340 nm.Although the quantum yield of the photolysis is rather low (ca 0.01), the photolysis proceeds fast and efficiently due to the large absorption coefficient of Pmoc-amino acid at around 340 nm.Thus, the use of Pmoc-amino acid as a "caged" amino acid is promising.
Okada, Shigeto,Yamashita, Senichi,Furuta, Toshiaki,Iwamura, Michiko
p. 431 - 434
(2007/10/02)

1-PYRENYLMETHYL ESTERS, PHOTOLABILE PROTECTING GROUPS FOR CARBOXYLIC ACIDS
1-Diazomethylpyrenes were prepared and reacted with carboxylic acids to give 1-pyrenylmethyl esters.The fluorescent esters were photolysed at 340 nm in methanol to form the starting acids and the corresponding 1-methoxymethylpyrenes in high yields.
Iwamura, Michiko,Ishikawa, Touru,Koyama, Yukiyoshi,Sakuma, Keisuke,Iwamura, Hiizu
p. 679 - 682
(2007/10/02)