- Pentafluorophenyl 4-nitrobenzenesulfonate as a peptide coupling reagent
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Protected dipeptides were obtained in good yield by coupling Boc- or Fmoc-protected amino acids with amino acid esters in the presence of pentafluorophenyl 4-nitrobenzenesulfonate (PFNB) as peptide coupling agent and 1-hydroxybenzotriazole as catalyst.
- Pudhom,Vilaivan
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- One-Pot Synthesis of Pentafluorophenyl Sulfonic Esters via Copper-Catalyzed Reaction of Aryl Diazonium Salts, DABSO, and Pentafluorophenol
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Pentafluorophenyl (PFP) sulfonic esters were synthesized via a copper-catalyzed one-pot multicomponent reaction of aryl diazonium tetrafluoroborate, DABSO (DABCO·(SO2)2), and pentafluorophenol. The reaction system provided the desired pentafluorophenyl sulfonic esters in good yields and exhibited excellent functional group tolerance. In addition, the generated PFP sulfonic esters were successfully applied in Sonogashira, Suzuki, Chan-Evans-Lam, and decarboxylative coupling reactions.
- Idris, Muhammad Aliyu,Lee, Sunwoo
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supporting information
p. 4516 - 4520
(2021/05/26)
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- Synthesis of aryl esters of protected amino acids from aryl sulfonates
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Aryl esters of Boc- and Fmoc-protected amino acids derived from electron-deficient phenols have been prepared in good yields from aryl 4- nitrobenzenesulfonates in the presence of 1-hydroxy-benzotriazole as catalyst.
- Pudhom, Khanitha,Vilaivan, Tirayut
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p. 5939 - 5942
(2007/10/03)
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