Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2′-Deoxyzebularine Embedded in Single-Stranded DNA
The APOBEC3 (APOBEC3A-H) enzyme family is part of the human innate immune system that restricts pathogens by scrambling pathogenic single-stranded (ss) DNA by deamination of cytosines to produce uracil residues. However, APOBEC3-mediated mutagenesis of vi
Kvach, Maksim V.,Barzak, Fareeda M.,Harjes, Stefan,Schares, Henry A. M.,Kurup, Harikrishnan M.,Jones, Katherine F.,Sutton, Lorraine,Donahue, John,D'Aquila, Richard T.,Jameson, Geoffrey B.,Harki, Daniel A.,Krause, Kurt L.,Harjes, Elena,Filichev, Vyacheslav V.
p. 1028 - 1035
(2020/01/02)
Efforts towards expansion of the genetic alphabet: Pyridone and methyl pyridone nucleobases
(Figure Presented) Getting on with it: A common problem with hydrophobic non-natural base pairs - the inefficient extension following such a base pair - is reduced by using the methylpyridone scaffold, which simultaneously limits another frequent problem
Leconte, Aaron M.,Matsuda, Shigeo,Hwang, Gil Tae,Romesberg, Floyd E.
p. 4326 - 4329
(2007/10/03)
Glycosylations of Ambident Anions of 2(1H)- and 4(1H)-Pyridone and Stereoselective Synthesis of 2(1H)-Pyrimidinone N-(2'-Deoxy-α-D-ribofuranoside)
Glycosylation of the ambident anions of 2(1H)-pyridone (6) and 4(1H)-pyridone (11) in the presence of KOH with 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride (7) stereoselectively yielded the β-D-O-glycosides 8 and 12, together with anom
Seela, Frank,Bindig, Uwe
p. 895 - 902
(2007/10/02)
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