cas 24649-22-7, 3-Chloro-1-methoxyisoquinoline | Articles data ｜lookchem

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24649-22-7

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Synthesis and Structure-Activity Relationships of 3-Arylisoquinolone Analogues as Highly Specific hCES2A Inhibitors
Mammalian carboxylesterases (CES) are key enzymes that participate in the hydrolytic metabolism of various endogenous and exogenous substrates. Human carboxylesterase 2A (hCES2A), mainly distributed in the small intestine and colon, plays a significant ro
Zhao, Yitian,Xiong, Yuan,Dong, Sanfeng,Guan, Xiaoqing,Song, Yunqing,Yang, Yanqing,Zou, Kun,Li, Zhao,Zhang, Yong,Fang, Shengquan,Li, Bo,Zhu, Weiliang,Chen, Kaixian,Jia, Qi,Ge, Guangbo
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p. 388 - 398
(2020/10/26)

QUINOLINE AND ISOQUINOLINE COMPOUNDS AND METHODS OF USE THEREOF
Provided herein are compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds a
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Page/Page column 90

(2012/03/26)

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Chemical Properties

Melting Point: 67-72°C
Boiling Point: 309.4 °C at 760 mmHg
Flash Point:140.9 °C
Density: 1.267 g/cm³
Vapor Pressure: 0.00116mmHg at 25°C
Refractive Index: 1.621
PKA: -0.47±0.30(Predicted)
PSA: 22.12000
LogP: 2.89680

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