- Non-luo kaoxi intermediate preparation method (by machine translation)
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The invention relates to a preparation method of the midbody non-luo kaoxi, belongs to the technical field of pharmacy. The invention provides a preparation method includes: a raw material first after the reaction with the acyl chloride reagent, with in addition a raw material in the presence of a reaction, after treatment, to obtain the target product. The method of the invention can be the operability is strong, is beneficial to the industrial production of operation and cost control. (by machine translation)
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Paragraph 0053; 0054; 0055; 0056; 0057; 0058; 0059; 0060
(2019/06/08)
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- A PROCESS FOR THE PREPARATION OF FIROCOXIB
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The present invention provides an improved process for preparation of Firocoxib of Formula I. Further, the present invention relates to novel process for the preparation of crystalline polymorphic form B of Firocoxib of Formula I.
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- Firocoxib preparation method
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The invention discloses a firocoxib preparation method and relates to the technical field of chemical synthesis, in particular to a novel method for synthesizing firocoxib. The novel method for synthesizing the firocoxib includes subjecting thioanisole serving as a raw material to acylation reaction, bromination reaction, oxidizing reaction, esterification reaction and cyclization reaction sequentially so as to obtain the firocoxib. Compared with a traditional technology, the novel method for synthesizing the firocoxib has the advantages that an aftertreatment process is simple without column chromatography separation, and the method is high in yield, low in cost and suitable for industrial production.
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- SAR in the alkoxy lactone series: The discovery of DFP, a potent and orally active COX-2 inhibitor
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Extensive SAR has been established in the alkoxy lactone series and this has lead to the discovery of DFP (5,5-dimethyl-3-(2-propoxy)-4- methanesulfonylphenyl)-2(5H)-furanone), a potent COX-2 inhibitor exhibiting in vivo efficacy in all models studied.
- Leblanc,Roy,Boyce,Brideau,Chan,Charleson,Gordon,Grimm,Guay,Leger,Li,Riendeau,Visco,Wang,Webb,Xu,Prasit
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p. 2207 - 2212
(2007/10/03)
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