Copper(II) pivalate/oxone: An improved promoter system for aryl transfer via organo-bismuth reagents
As part of a medicinal chemistry project, it was necessary to develop effective conditions for the arylation of hydroxyl groups prone to elimination. Modest success was achieved using triarylbismuth reagents under literature conditions. Based on the side
Copper-Catalyzed Electrophilic Amination of Alkoxyarylsilanes
We report a copper-catalyzed amination reaction between simple alkoxyarylsilanes and N-benzoyloxyamines. Silver fluoride serves as a stoichiometric base as well as an indispensable activator that allows the catalytic process to proceed. Multiply alkoxylated arylsilanes, such as trialkoxyarylsilanes and dialkoxyarylsilanes were transformed into the corresponding tertiary anilines under mild reaction conditions.
Provided are compounds of formula I and formula II or pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The compounds of formula I and formula II or the pharmaceutically acceptable salts of the compounds provide indole 2,3-dioxygenase (IDO) inhibitory activity and are capable of treating IDO-mediated immunosuppressive diseases, such as infectious diseases or cancer.
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Paragraph 0675-0676
(2019/01/04)
1, 4-DISUBSTITUTED PIPERIDINES AS VASOPRESSIN RECEPTOR VIA ANTAGONISTS
The present invention provides compounds of formula (1) compositions comprising such compounds; the use of such compounds in therapy (such as in the treatment of dysmenorrhoea); and methods of treating patients with such compounds; wherein A and G are as defined herein.
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Page/Page column 40; 42
(2010/09/17)
DIHYDROPYRAZOLOPYRIDINE COMPOUNDS
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Page 42-43
(2010/02/06)
INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras
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(2008/06/13)
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