- Stability of amitriptyline hydrochloride in a commercial aqueous solution
-
A commercial amitriptyline hydrochloride solution was stored at 80° for up to 3 months. High-performance liquid chromatography showed no evidence of amitriptyline hydrochloride degradation. The method also indicated that two reported degradates, 3-(propa-1,3-dienyl)-1,2:4,5-dibenzocyclohepta-1,4-diene and dibenzosuberone, were present at levels less than 0.1% (the detection limit of the method) under the storage conditions. The stability of the commercial solutions is attributed to their relatively low ratio of headspace oxygen to amitriptyline hydrochloride.
- Roman,Cohen,Christy,Hagerman
-
-
Read Online
- NOVEL TRICYCLIC, BICYCLIC, MONOCYCLIC, AND ACYCLIC AMINES AS POTENT SODIUM CHANNEL BLOCKING AGENTS
-
The present invention provides acyclic, bicyclic, monocyclic, and tricyclic analogs and derivatives of tricyclic antidepressants which have sodium channel inhibiting activity. The compounds of the invention are useful as analgesics and anesthetics for diseases, conditions, and disorders where regulation of sodium channel activity can alleviate pain.
- -
-
Page/Page column 37
(2008/06/13)
-
- Decomposition of amitriptyline hydrochloride in aqueous solution: identification of decomposition products
-
The decomposition of amitriptyline hydrochloride upon autoclaving in a buffered solution (pH 6.8) was investigated. Three major decomposition products [3 (propa 1,3 dienyl) 1,2:4,5 dibenzocyclohepta 1,4 diene, dibenzosuberone, and 3 (2 oxoethylidene) 1,2:4,5 dibenzocyclohepta 1,4 diene] were detected and identified by chromatographic and spectroscopic techniques. Evidence is presented that the latter two compounds are formed by further oxidation of 3 (propa 1,3 dienyl) 1,2:4,5 dibenzocyclohepta 1,4 diene, and a possible decomposition pathway is outlined.
- Enever,Li Wan Po,Millard,Shotton
-
p. 1497 - 1499
(2007/10/05)
-