Synthesis of new aryl substituted furan-2(5H)-ones using the Suzuki-Miyaura reaction
A series of novel 5-arylidenefuran-2(5H)-ones and 5-arylidene-4-arylfuran- 2(5H)-ones were synthesized via the Suzuki-Miyaura reactions of fimbrolide derivatives 5-(bromomethylene)furan-2(5H)-one and 4-bromo-5-(bromomethylene) furan-2(5H)-one, respectivel
A new, highly stereoselective synthesis of β-unsubstituted (Z)-γ-alkylidene-butenolides using bromine as a removable stereocontrol element
Several β-unsubstituted (Z)-γ-alkylidenebutenolides have been prepared in highly stereocontrolled fashion by implementing a steric directing group stratagem in the vinylogous aldol condensation of butenolides with aldehydes. Applications to the synthesis of the antitumor heptene (S)-melodorinol and a thiophenelactone from Chamaemelum nobile L. are described. Georg Thieme Verlag Stuttgart.
Boukouvalas, John,Beltrán, Paola P.,Lachance, Nicolas,C?té, Sébastien,Maltais, Fran?ois,Pouliot, Martin
p. 219 - 222
(2007/10/03)
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