- ISOQUINOLINE COMPOUNDS AND THEIR USE IN TREATING AhR IMBALANCE
-
The present invention is directed to novel compounds of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof. Pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt, solvate or hydrate thereof, are also described. The invention is also directed to use of the compounds of Formula (I) for treating a condition in a mammal associated with AhR imbalance, such as an inflammatory disease or disorder.
- -
-
-
- (Cin = Cinnamyl): A versatile catalyst for C-N and C-C bond formation
-
[Pd(IPr*OMe)(cin)(Cl)] provides high catalytic activity for Buchwald-Hartwig cross-coupling reactions of sterically demanding aryl chlorides with sterically hindered and deactivated aniline derivatives. This catalyst also proved efficient in Suzuki-Miyaura reactions, thus allowing the preparation of tetra-ortho-substituted biaryls. The Kumada-Corriu coupling has also been investigated using this palladium N-heterocyclic carbene (NHC) catalyst.
- Bastug, Gulluzar,Nolan, Steven P.
-
p. 1253 - 1258
(2014/04/03)
-
- A simple and efficient total synthesis of (±)-danshexinkun A, a bioactive diterpenoid from Salvia miltiorrhiza
-
An efficient 12-step route for the synthesis of the diterpenoid quinone (±)-danshexinkun A in 23% overall yield from the corresponding highly substituted stilbene using a photocyclization strategy is described.
- Moghaddam, Firouz Matloubi,Farimani, Mahdi Moridi
-
supporting information; experimental part
p. 540 - 542
(2010/10/02)
-
- Approach to the synthesis of candelabrone and synthesis of 3,7-diketo-12-hydroxyabieta-8,11,13-triene
-
An approach to the synthesis of aromatic diterpenes was tested for its generality.Phenylacetonitriles with increasing substitution on the aromatic ring were prepared and alkylated with geranyl bromide and the resulting dienes subjected to cationic cycliza
- Burnell, Robert H.,Caron, Stephane
-
p. 1446 - 1454
(2007/10/02)
-