Influence of the substitution pattern on the Pb(OAc)4 mediated oxidative cleavage of steroidal 1,2-diols
A rapid increase in molecular complexity, modulated by the substitution pattern, upon treatment of steroidal unsaturated diols with lead tetraacetate is presented. The steric and electronic factors involved in these cascade type transformations are investigated, the products serving as useful mechanistic probes.
Martin Hernando, Jose Ignacio,Rico Ferreira, Maria Del Rosario,Candela Lena, Jose Ignacio,Toupet, Loic,Birlirakis, Nicolas,Arseniyadis, Simeon