- Preparation method of myocardial protection medicine
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The invention discloses a preparation method of a myocardial protection medicine, belonging to the field of medicinal chemistry. The preparation method of the medicine comprises the following steps: carrying out a reflux reaction on creatinine and phosphorus oxychloride to prepare creatinine phosphoryl chloride, then subjecting the creatinine phosphoryl chloride to reacting with a sodium hydroxide solution to prepare a crude creatinine phosphate sodium product, and conducting refining to obtain a refined creatinine phosphate sodium product. According to the invention, product yield and quality are improved, reaction conditions in a preparation process are mild, production cost is low, a used solvent is safe and environment-friendly, and the method is suitable for industrial mass production.
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Paragraph 0024; 0033-0035; 0036-0038; 0039-0041; 0042-0044
(2021/07/01)
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- A preparation method of creatinine
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The invention belongs to the technical field of chemical synthesis, in particular relates to a preparation method of creatinine, the method to creatine as the starting material, and containing 2 - 5 carbon of the lower saturated fatty acid reaction. The method of environmental protection, without by-product to produce, almost zero-emission, without refining can be directly used for cardiac muscle protective drug creatine phosphate sodium synthetic.
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Paragraph 0044; 0047; 0048
(2019/03/31)
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