- Chemical modification of poly(vinylacetylene) and synthesis of poly(1,2,3-triazole)s
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A series of new polymers containing 1,2,3-triazoles were synthesized and their structures and properties were characterized by FT-IR, 1H NMR, TGA, DSC and GPC. The results showed that the polymers modified by alkyl groups had good solubility, thermal stability and reasonable molecular weights. It was also demonstrated that the properties of fluorine-containing polymers were seriously affected by fluorine atoms with hydrophobic and chemical proof properties.
- Wang, Lian-Jun,Liao, Shan,Wang, Le-Yong
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- Catalytic mesylation of alcohols: A highly productive process for trifluoroethyl mesylate
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"Intermediate" Lewis acids are efficient catalysts for mesylation of trifluoroethanol (TFE) by mesyl chloride at 80 °C. In the absence of solvent, trifluoroethyl mesylate (TFEMes) is obtained in a chemical yield of 98% with total conversion of TFE. The only coproduct of the reaction, hydrochloric acid, simply distills from the reaction mixture. Distillation of TFEMes allows for recycle of the catalyst without any treatment.
- Vastra, Johann,Saint-Jalmes, Laurent
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- Olefination with Sulfonyl Halides and Esters: Scope, Limitations, and Mechanistic Studies of the Hawkins Reaction
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Carbanions of alkanesulfonyl halides and esters react with nonenolizable carbonyl compounds to give olefins. Mechanistic studies reveal that initial aldol-type addition of the carbanions is followed by cyclization-fragmentation to alkenes, and the leaving group on the sulfonyl moiety (RSO2X) controls carbanion stability and rate of the olefin formation.
- Górski, Bartosz,Talko, Alicja,Basak, Tymoteusz,Barbasiewicz, Micha?
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supporting information
p. 1756 - 1759
(2017/04/11)
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- DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5- AMINE
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The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.
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Paragraph 0427
(2015/07/07)
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- ADRENERGIC RECEPTOR ANTAGONISTS
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The present invention relates to α1a and/or α1b adrenergic receptor antagonists, which can be used to treat a disease or disorder mediated through α1a and/or α1b adrenergic receptors. Compounds and pharmaceutical compositions disclosed herein can be used to treat benign prostatic hyperplasia (BPH) and related symptoms thereof. Further, such compounds can be used to treat lower urinary tract symptoms that may or may not be associated with BPH. The present invention also relates to processes to prepare the disclosed compounds, pharmaceutical compositions thereof, and methods of treating BPH or related symptoms thereof.
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Page/Page column 49-50
(2010/11/24)
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- A method of hydroxylation org. compd. sulfonylated
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The invention concerns a method for sulphonylating a hydroxylated organic compound. The invention concerns in particular aliphatic hydroxylated compounds and more particularly those which comprise on their aliphatic chain, an electroattractive group. The
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- Method for sulphonylating a hydroxylated organic compound
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The invention concerns a method for sulphonylating a hydroxylated organic compound. The invention concerns in particular aliphatic hydroxylated compounds and more particularly those which comprise on their aliphatic chain, an electroattractive group. The
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- Pharmaceutical use of N-carbamoylazole derivatives
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The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a
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- Pharmaceutical use of N-Carbamoylazole derivatives
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The present invention relates to use of 1-carbamoylazole derivatives as medicaments and pharmaceutical compositions containing 1-carbamoylazole derivatives as the active ingredient, based on their DPPIV inhibiting effects. The present invention provides a dipeptidyl peptidase IV inhibiting agent comprising a compound represented by the general formula (I):
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- Electronic properties of the nitrone substituent. Stabilization of benzylic carbocations
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The nitrone substituent CH=N(O) t-Bu is electron-withdrawing with a Taft σI value of 0.20. It also retards the solvolysis rate of a cumyl chloride when placed in the meta-position (σ = 0.20). However, CH=N(O) t-Bu becomes weakly cation stabilizing when placed in the para-position of a cumyl cation (σ+ = -0.04). This weak cation stabilization is a result of a conjugative interaction which delocalizes charge and offsets the inductive effect of the nitrone. When the nitrone is placed in the para-position, but then twisted out of conjugation with the aromatic ring by incorporation of flanking 3,5-dimethyl groups, it again retards solvolysis rates. Computational studies (B3LYP/6-31G*) show that the nitrone substituent stabilizes a para-substituted benzyl cation relative to the meta-substituted analog by a conjugative interaction. However, the calculated stabilization greatly overestimates the cation stabilization seen in solvolytic reactions. Copyright
- Creary, Xavier,Hartandi, Kresna
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- Various synthetic approaches to fluoroalkyl p-nitrophenyl ethers
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Homologous 1H,1H-perfluoroalkyl p-nitrophenyl ethers (alkyl = C2-C8) were synthesized using different methods. The results are discussed in context with contradictory comments of the literature. The fluoroalkoxylation of p-chloronitrobenzene occurs in only one step, but it is limited to small fluoroalkyl groups. The fluoroalkylation of p-nitrophenol via sulphonic acid esters is a better synthetic route. Differences in reactivity and yield between tosylates, mesylates and inflates are found and discussed. The preferred synthesis includes the use of trifluoromethane sulphonic acid esters.
- Preschera, Dietrich,Thiele, Thomas,Ruhmann, Ralf
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p. 145 - 148
(2007/10/03)
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- Novel substituted aromatic compounds
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Substituted phenoxy, phenylthio and anilino compounds, intermediates therefor, synthesis thereof, and their use for the control of pests.
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