- Tackling poison and leach: Catalysis by dangling thiol-palladium functions within a porous metal-organic solid
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Self-standing thiol (-SH) groups within a Zr(iv)-based metal-organic framework (MOF) anchor Pd(ii) atoms for catalytic applications: the spatial constraint prevents the thiol groups from sealing off/poisoning the Pd(ii) center, while the strong Pd-S bond precludes Pd leaching, enabling multiple cycles of heterogeneous catalysis to be executed. This journal is
- Gui, Bo,Yee, Ka-Kit,Wong, Yan-Lung,Yiu, Shek-Man,Zeller, Matthias,Wang, Cheng,Xu, Zhengta
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supporting information
p. 6917 - 6920
(2015/04/22)
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- PROCESS FOR THE PREPARATION OF IOPAMIDOL
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The present invention discloses a process for the preparation of Iopamidol of formula (II) and comprising the following steps: a) reacting the Compound (I) wherein X is OR2 or R3, and wherein R2 and R3 are a Ci-C6 linear or branched alkyl, C3-C6 cycloalkyl, C6 aryl, optionally substituted with a group selected from the group consisting of methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl, t-butyl and phenyl, with the acylating agent (S)-2-(acetyloxy)propanoyl chloride in a reaction medium to provide the acetyloxy derivative of Compound (I); b) hydrolyzing the intermediate from step a) with an aqueous solution at a pH comprised from 0 to 7, by adding water or a diluted alkaline solution such as sodium hydroxide or potassium hydroxide, freeing the hydroxyls from the boron-containing protective groups, obtaining the N-(S)-2-(acetyloxy)propanoyl derivative of Compound (II); c) alkaline hydrolysis to restore the (S)-2-(hydroxy)propanoyl group and to obtain lopamidol (II) and optional recovery of the boron derivative from the solution obtained in step b). The boron-containing protective group is versatile, efficient and recyclable. A one-pot synthesis, without intermediate isolation is provided, leading to a decreasing of recovered and recycled solvents and a significant increasing in the yield, representing a significant advantage in terms of cost-effectiveness of the entire process and environmental awareness.
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- Arylamide dendrimers with flexible linkers via haloacyl halide method
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(Chemical Equation Presented) Soluble arylamide dendrons with flexible linkers, peripheral ester or carboxyl groups (R), and focal amino or halogen functionalities (F) were synthesized from aryl glycineamide (AG) building blocks. The AG blocks were prepar
- Vinogradov, Sergei A.
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p. 1761 - 1764
(2007/10/03)
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- Process for the preparation of n,n-substituted 5-amino-1,3-benzenedicarboxamides
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The invention relates to a process for the preparation of a compound of formula (I), wherein R represents a 2,3-dihydroxy-1-propyl or a 1,3-dihydroxy-2-propyl radical, via direct amidation of a dialkyl ester of 5-amino-1,3-benzenedicarboxylic acid of formula (V), wherein R1 represents a straight or branched (C1-C4)-alkyl group, with at least the stoichiometric amount of an amine of formula H2NR.
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