- Synthesis method of Guerbet acid
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The invention discloses a synthesis method of Guerbet acid, and belongs to the technical field of chemical synthesis. The synthesis method comprises the following steps: adding long-chain saturated fatty acid ester, alkali and a solvent into a reaction kettle, slowly adding an alkylation reagent, heating to react, cooling, and carrying out reduced pressure distillation to remove the solvent, thereby obtaining dialkyl acetate; adding alcohol, water and a catalyst into the reaction kettle, heating for reaction, and performing reduced pressure distillation to remove the solvent; and adding waterinto the reaction kettle, adjusting the pH value of the system to 3-4, separating the liquid, dissolving the organic phase in petroleum ether, washing, decolorizing, and carrying out reduced pressuredistillation to obtain Guerbet acid. The method has few steps and is easy to operate and has low requirements on equipment; reaction selectivity is high, the conversion rate is high, impurities are few, and yield and purity are high; the main chain and branched chain structures of the product Guerbet acid can be flexibly regulated and controlled, and the raw materials are diversified; and the method is short in time consumption, less in generated waste, environment-friendly, safe and suitable for industrial production.
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Paragraph 0045; 0049-0050
(2020/07/02)
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- CATIONIC LIPIDS FOR NUCLEIC ACID DELIVERY AND PREPARATION THEREOF
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The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.
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Page/Page column 68; 85; 86
(2018/05/27)
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- Extraction of metal values
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Metal values, especially copper values, are extracted from aqueous solutions of metal salts containing halide or pseudo halide ions by a 1,2,4 triazole substitued in the 1- position by (1) a hydrocarbyl (alkyl) group or (2) a group of the formula --(X)n --(CO--Y)m where X is an optionally substituted methylene, vinylene or phenylene linking group or a linking group of formula --CO--A-- where A is an optionally substituted aromatic ortho linking group; n is 0 or 1; Y is OR2 or R3 where R2 and R3 are hydrocarbyl groups containing from 5 to 36 carbon atoms (preferably branched alkyl groups containing from 9 to 24 carbon atoms); and m is from 1 to 3.
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- Model compounds for biodegradation studies on hydrocarbon-type dielectric fluids
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The hydrocarbons 7-methylpentadecane (1, n = 0) and 7-methyl-9-n-hexyl heptadecane (1, n = 1) have been synthesized.These compounds are suitable as model compounds for biodegradation studies on mixtures of oligomers of 1-octene and related compounds which have been proposed as dielectric fluids for the replacement of PCB's.The synthesis confirms the feasibility of isotope labelling for such biodegradation studies.
- Baarschers, Willem Hendrik,Li, Maria Angela
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p. 1784 - 1787
(2007/10/02)
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