- Chemical and biological profile of racemic and optically active dialkylaminoalkylnaphthalenes with analgesic activity
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The racemic mixtures and the enantiomers of dialkylaminoalkylnaphthalenes are described here as novel analgesic agents with potencies similar, or superior to that of morphine. The synthesis and isolation of the pure enantiomers and a study of the absolute
- Azzolina, Ornella,Collina, Simona,Brusotti, Gloria,Rossi, Daniela,Callegari, Athos,Linati, Laura,Barbieri, Annalisa,Ghislandi, Victor
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- Synthesis and characterization of novel zinc precursors for ZnO thin film deposition by atomic layer deposition
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A novel series of zinc complexes, [EtZn(dab)]2 (1), [EtZn(damb)]2 (2), [EtZn(damp)]2 (3), and [EtZn(dadb)]2 (4), were prepared via single-step substitution. Further, these were analyzed by nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR), elemental analysis, single crystal X-ray diffraction analysis, and thermogravimetric analysis (TGA). The X-ray crystallography analysis revealed that all complexes exist as dimeric structures with distorted tetrahedral geometry having zinc centers that are interconnected via μ2-O bonding of the aminoalkoxy oxygen atom. TGA and thermal analysis of the complexes showed high volatilities and stabilities at sublimation temperatures of 70, 95, 90, and 105 °C at 0.5 Torr for the respective compounds. Precursor 3 was successfully used for ZnO thin film deposition by ALD. A growth rate per cycle (GPC) of 0.125 nm per cycle was obtained at 200 °C and XPS analysis confirmed the growth of highly pure ZnO films without carbon and nitrogen impurities, while XRD analysis revealed the deposition of reasonably crystalline films. Additionally, the high transmittance and wide bandgap of the films are suitable for optoelectronic applications.
- Agbenyeke, Raphael Edem,Chung, Taek-Mo,Han, Seong Ho,Kim, Chang Gyoun,Lee, Ga Yeon,Lee, Young Kuk,Park, Bo Keun,Son, Seung Uk
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- Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines
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Sigma Receptor (SR) modulators are involved in different signal transduction pathways, representing important pharmacological/therapeutic tools in several pathological conditions, such as neurodegenerative diseases and cancers. To this purpose, numerous c
- Rossi, Daniela,Rui, Marta,Di Giacomo, Marcello,Schepmann, Dirk,Wünsch, Bernhard,Monteleone, Stefania,Liedl, Klaus R.,Collina, Simona
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- A novel method for biomimetic synthesis of Mannich bases
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Since the early studies of Mannich, Mannich reaction has become an important tool for the synthesis of new compounds. Mannich bases can be either directly employed or used as intermediates. In this work, the one-carbon unit transfer reaction of tetrahydrofolate coenzyme was initiated. 1,3-Dimethylimidazolidine as a new tetrahydrofolate coenzyme model at formaldehyde oxidation level was used to react with ketone having active hydrogen atoms and amine to give the corresponding Mannich base in good yield by a covert Mannich reaction. A novel method for biomimetic synthesis of various Mannich bases is provided. 1,3-Dimethylimidazolidine as a new tetrahydrofolate coenzyme model at formaldehyde oxidation level was used to react with ketone having active hydrogen atoms and amine to give the corresponding Mannich base in good yield by a covert Mannich reaction. A novel method for biomimetic synthesis of various Mannich bases is provided. Copyright
- Guo, Yuan,An, Jing,Lu, Zhenhuan,Peng, Mengjiao
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experimental part
p. 1561 - 1564
(2012/10/07)
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- Identification of a potent and selective ρ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells
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Herein we report the synthesis, drug-likeness evaluation, and in vitro studies of new sigma (ρ) ligands based on arylalkenylaminic scaffold. For the most active olefin the corresponding arylalkylamine was studied. Novel arylalkenylamines generally possess
- Rossi, Daniela,Pedrali, Alice,Urbano, Mariangela,Gaggeri, Raffaella,Serra, Massimo,Fernández, Leyden,Fernández, Michael,Caballero, Julio,Ronsisvalle, Simone,Prezzavento, Orazio,Schepmann, Dirk,Wuensch, Bernhard,Peviani, Marco,Curti, Daniela,Azzolina, Ornella,Collina, Simona
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scheme or table
p. 6210 - 6224
(2011/12/02)
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- N-donor ligand as catalyst: A simple Aza-Michael addition reaction in aqueous media
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(Chemical Equation Presented) A novel approach for the Aza-Michael addition reactions between various amines and α,β-unsaturated esters, nitriles and ketones using N-donor Ligand catalyst (3 mol %) is described. The reactions are carried out in aqueous media at an ambient temperature to afford the products in excellent yields.
- Pawar, Shivaji S.,Dekhane, Deepak V.,Shingare, Murlidhar S.,Thore, Shivaji N.
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experimental part
p. 1869 - 1873
(2009/06/18)
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- Design, synthesis, and SAR analysis of novel selective σ1 ligands
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A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to σ1 and σ2 receptors. Many compounds exhibited nanomolar affinity for σ1 subtype receptor with good selectivity over σsub
- Collina, Simona,Loddo, Guya,Urbano, Mariangela,Linati, Laura,Callegari, Athos,Ortuso, Francesco,Alcaro, Stefano,Laggner, Christian,Langer, Thierry,Prezzavento, Orazio,Ronsisvalle, Giuseppe,Azzolina, Ornella
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p. 771 - 783
(2007/10/03)
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- Ceric ammonium nitrate catalyzed aza-Michael addition of aliphatic amines to α,β-unsaturated carbonyl compounds and nitriles in water
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Ceric ammonium nitrate (3 mol%) efficiently catalyzes the aza-Michael reaction of amines with α,β-unsaturated carbonyl compounds in water to produce the corresponding β-amino carbonyl compounds in good to excellent yields (55-99%) for most of the compounds under mild conditions. The reaction is procedurally simple and displays limited chemoselectivity, as aromatic amines were found to be unreactive. Georg Thieme Verlag Stuttgart.
- Varala, Ravi,Sreelatha, Nuvula,Adapa, Srinivas R.
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p. 1549 - 1553
(2007/10/03)
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