An approach to the synthesis of 4-aryl and 5-aryl substituted thiazole-2(3: H)-thiones employing flow processing
A method for the preparation of 4-aryl and 5-aryl substituted thiazole-2(3H)-thiones is described. Flow processing is employed as a tool, and supported acids and bases used to facilitate both the synthetic strategy and product isolation. The methodology is applicable to a range of substrates.
Balti, Monaem,Miller, Shelli A.,Efrit, Mohamed Lotfi,Leadbeater, Nicholas E.
p. 72165 - 72169
(2016/08/09)
Thiazoles and thiopyridines: Novel series of high affinity h5HT 7 ligands
A series of thiazole based 5HT7 ligands has been identified from screening. Optimisation of the pendent aryl group and modification of the core gave a related series of high affinity, selective thiopyridine based 5HT7 ligands, the most active of which behaves as a partial agonist.
Thomson, Christopher G.,Beer, Margaret S.,Curtis, Neil R.,Diggle, Helen J.,Handford, Emma,Kulagowski, Janusz J.
p. 677 - 680
(2007/10/03)
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