cas 254892-99-4, 3-(4-BORONOPHENYL)CYCLOBUTANONE ETHYLENE KETAL | Articles data ｜lookchem

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254892-99-4

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4-Dihydroxyborylphenyl Analogues of 1-Aminocyclobutanecarboxylic Acids: Potential Boron Neutron Capture Therapy Agents
A series of 4-dihydroxyborylphenyl analogues of an unnatural α-amino acid, 1-aminocyclobutanecarboxylic acid (ACBC), was synthesized. Varying numbers of methylene units were introduced between the 4-boronophenyl and ACBC moieties in order to introduce different degrees of lipophilicity into the molecules. The key step in the syntheses was the preparation of the precursor p-boronophenyl-substituted cyclobutanones which were subsequently converted to the desired amino acids via the Bucherer-Strecker reaction.
Srivastava, Rajiv R.,Singhaus, Robert R.,Kabalka, George W.
p. 8495 - 8500
(2007/10/03)

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Chemical Properties

Boiling Point: 419.5 °C at 760 mmHg
Flash Point:207.5 °C
Density: 1.29 g/cm³
Vapor Pressure: 8.66E-08mmHg at 25°C
Refractive Index: 1.581
PSA: 58.92000
LogP: -0.01310

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