Imidazoline derivatives as alpha-1A adrenoceptor ligands
Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.
The structure-activity relationship of 2′-pyrrole, pyrazole and triazole substituted 2-(anilinomethyl)imidazolines as α1 adrenergic agonists was investigated. The size and orientation of substituents, as well as the position of the heteroatoms, were found to have a profound effect on the potency and selectivity of the molecules. Potent α1A subtype selective agonists have been identified.
Speake, Jason D.,Navas III, Frank,Bishop, Michael J.,Garrison, Deanna T.,Bigham, Eric C.,Hodson, Stephen J.,Saussy, David L.,Liacos, Jim A.,Irving, Paul E.,Sherman, Bryan W.
p. 1183 - 1186
(2007/10/03)
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