cas 256328-82-2, DESTHIAZOLYLMETHYL RITONAVIR | Articles data ｜lookchem

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256328-82-2

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Application of Isayama–Mukaiyama cobalt catalyzed hydroperoxysilylation for the preparation of ritonavir hydroperoxide
We report the preparation of thiazol-5-ylmethyl ((2S,3S,5S)-5-((S)-2-(3-((2-(2-hydroperoxypropan-2-yl)thiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamido)-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate, a hydroperoxide impurity of ritonavir also known as
Gazal, Sharon,Gupta, Priya,Gunturu, Siva Ramakrishna,Isherwood, Matthew,Voss, Matthew E.
p. 5099 - 5102
(2016)
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Pharmaceutical formulations
Improved pharmaceutical compositions are provided comprising one or more solubilized HIV protease inhibiting compounds having improved solubility properties in a medium and/or long chain fatty acid, or mixtures thereof, a pharmaceutically acceptable alcoh
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Page/Page column 16

(2008/06/13)

Polymorph of a pharmaceutical
A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.
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Page 4

(2008/06/13)

POLYMORPH OF RITONAVIR
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Page 5

(2008/06/13)

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Chemical Properties

Melting Point: 65-69°C
Boiling Point: 874.007°C at 760 mmHg
Flash Point:482.382°C
Density: 1.185g/cm³
Solubility:Chloroform (Slightly), DMSO (Slightly, Sonicated), Methanol (Slightly)
Storage Temp.:Refrigerator
Vapor Pressure: 0mmHg at 25°C
PKA: 12.40±0.46(Predicted)
PSA: 140.90000
LogP: 6.38040

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